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Salivary C-Reactive Protein

Technical Summary

Analyte Summary:
Analyte: C-Reactive Protein
Aliases: CRP
Serum-Saliva Correlation: NA
Optimum Collection Volume: 125 μL*
*Add 300 µl to the total volume of all tests for liquid handling
Special Considerations
Passive Drool is a Preferred Collection Method

CRP is Location Dependent
Assay Summary:
Methodology: ELISA
Sensitivity: 10 pg/mL
Assay Range: 93.75 pg/mL - 3000 pg/mL
Assay Type: Quantitative

Collect Saliva Samples


Better results begin with better saliva collection. This collection protocol features general considerations to maximize salivary C-Reactive Protein analysis. Use this analyte-specific collection protocol to plan your collection methodology and sampling schemes.


Test Saliva Samples

@ Salimetrics
Salimetrics SalivaLab - Easy & Accurate
Order Code (lab): 5417
Transport Requirements: Ship on Dry Ice
@ Your Own Lab
Salimetrics Assay Kits - Better Results

Add DNA Analysis to My Study

Considerations for adding Salivary DNA to analyte Studies:

You can combine salivary analytes with easy, accurate, and affordable genomic testing using Salimetrics SalivaLab and the same sample that you are already collecting – no specialized saliva collection devices or additional samples are required.

Don’t know what SNPs are right for you? The SalivaLab’s DNA team specializes in genetic testing services, we recommend you Request a DNA Consult (gratis) to learn more about common considerations such as # of samples, participant ethnicity, and IRB Approval.

All DNA Services

DNA Extraction and Normalization
Single Nucleotide Polymorphism (SNP) Genotyping
VNTR & STR Analysis

References & Salivary C-Reactive Protein Research

    1. Ridker, P.M. (2003). Clinical application of C-reactive protein for cardiovascular disease detection and prevention. Circulation, 107(3), 363-9.
    2. Pearson, T.A., Mensah, G.A., Alexander, R.W., et al. (2003). Markers of inflammation and cardiovascular disease: Application to clinical and public health practice. A statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. Circulation,107(3), 499- 511.
    3. Buffon, A., Liuzzo, G., Biasucci, L.M., et al. (1999). Preprocedural serum levels of C-reactive protein predict early complications and late restenosis after coronary angioplasty. J Am Coll Cardiol, 34(5), 1512-21.
    4. Danesh, J., Wheeler, J.G., Hirschfield, G.M., et al. (2004). C-Reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease. N Engl J Med, 350(14), 1387-97.
    5. Sesso, H.D., Buring J.E., Rifai, N., et al. (2003). C-Reactive protein and the risk of developing hypertension. JAMA, 290(22), 2945-51.
    6. Blake, G.J., Rifai, N., Buring, J.E., & Ridker, P.M. (2003). Blood pressure, C-reactive protein, and risk of future cardiovascular events. Circulation, 108(24), 2993-9.
    7. Dehghan, A., Kardys, I., de Maat, M.P., et al. (2007). Genetic variation, C-reactive protein levels, and incidence of diabetes. Diabetes, 56(3), 872-8.
    8. Pradhan, A.D., Manson, J.E., Rifai, N., et al. (2001). C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. JAMA, 286(3), 327-34.
    9. Du Clos, T.W. Editorial: C-reactive protein as a regulator of autoimmunity and inflammation. (2003). Arthritis Rheum, 48(6), 1475-77.
    10. Krasteva, A., Perenovska, P., Ivanova, A., et al. (2010).  Alteration in salivary components of children with allergic asthma.  Biotechnology Biotehnological Equipment, 24(2), 1866-69.

    1. Gutiérrez, A.M., Martínez-Subiela, S., Soler, L., et al. (2009).  Use of saliva for haptoglobin and C-reactive protein quantifications in porcine respiratory and reproductive syndrome affected pigs in field conditions.  Vet Immunol Immunopathol, 132(2-4), 218-23.
    2. Salimetrics internal data.
    3. Giannobile, W.V., Beikler, T., Kinney, J.S., et al. (2009). Saliva as a diagnostic tool for periodontal disease: Current state and future directions.  Periodontol 2000, 50, 52-64.
    4. Higashi, Y., Goto, C., Jitsuiki, D., et al. (2008).  Periodontal infection is associated with endothelial dysfunction in healthy subjects and hypertensive patients.  Hypertension, 51(2), 446-53.
    5. Miller, C.S., Foley, J.D., Bailey, A.L., et al. (2010).  Current developments in salivary diagnostics.  Biomark Med, 4(1), 171-89.
    6. Floriano, P.N., Christodoulides, N., Miller, C.S., et al. (2009). Use of saliva-based nano-biochip tests for acute myodardial infarction at the point of care: A feasibility study.  Clin Chem, 55(8), 1530-38.
    7. Gómez-Laguna, J. Gutiérrez, A., Pallarés, F.J., et al. (2010). Haptoglobin and C-reactive protein as biomarkers in the serum, saliva and meat juice of pigs experimentally infected with porcine reproductive and respiratory syndrome virus.  Vet J, 185(1), 83-7.
    8. Gutiérrez, A.M., Martínez-Subiela, S., Eckersall, P.D., Cerón, J.J. (2008). C-reactive protein quantification in porcine saliva: A minimally invasive test for pig health monitoring.  Vet J, 181(3), 261-5.
    9. Tonetti, M.S., D’Aiuto, F., Nibali, L., et al. (2007). Treatment of periodontitis and endothelial function. N Engl J Med, 356(9), 911-20.
    10. D’Aiuto, F., Ready, D., Tonetti, M.S. (2004). Periodontal disease and C-reactive protein-associated cardiovascular risk. J Periodont Res, 39(4), 236-41.