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Salivary Interleukin-1 Beta

Technical Summary

Analyte Summary
Analyte: Interleukin-1 Beta
Aliases: IL-1B, IL-1 Beta, IL-1B, IL1β
Serum-Saliva Correlation: NA
Optimum Collection Volume: 50 μL*
*Add 300 µl to the total volume of all tests for liquid handling loss
Special Considerations
IL-1 Beta may be Flow Rate Dependent
Assay Summary
Methodology: ELISA
Sensitivity: <0.37 pg/mL
Assay Range: 3.13 pg/mL - 200 pg/mL
Assay Type: Quantitative

Collect Saliva Samples

IL-1 BETA SALIVA COLLECTION CONSIDERATIONS

Better results begin with better saliva collection. This collection protocol features general considerations to maximize salivary IL-1 Beta analysis. Use this analyte specific collection protocol to plan your collection methodology and sampling schemes.

APPROVED SALIVARY IL-1 BETA COLLECTION METHODS

Test Saliva Samples

@ Salimetrics
Salimetrics SalivaLab - Easy & Accurate
Order Code (lab): 5400.01
Transport Requirements: Ship on Dry Ice
Related Panels and Profiles: Salivary Cytokine Panel
@ Your Own Lab
Salimetrics Assay Kits - Better Results

Add DNA Analysis to My Study

Considerations for adding Salivary DNA to analyte Studies:

You can combine salivary analytes with easy, accurate, and affordable genomic testing using Salimetrics SalivaLab and the same sample that you are already collecting – no specialized saliva collection devices or additional samples are required.

Don’t know what SNPs are right for you? The SalivaLab’s DNA team specializes in genetic testing services, we recommend you Request a DNA Consult (gratis) to learn more about common considerations such as # of samples, participant ethnicity, and IRB Approval.

All DNA Services

DNA Extraction and Normalization
Single Nucleotide Polymorphism (SNP) Genotyping
VNTR & STR Analysis

References & Salivary IL-1 Beta Research

  1. Giannobile, W.V., Beikler, T., Kinney, J.S., et al. (2009).  Saliva as a diagnostic tool for periodontal disease: Current state and future directions.  Periodontology 2000, 50, 52-64.
  2. Pirhonen, J., Sareneva, R., Kurimoto, M., et al. (1999).  Virus infection activates IL-1β and IL-18 production in human macrophages by a caspase-1-dependent pathway.  J Immunol, 162(12), 7322-29.
  3. Park, D.R., Thomsen, A.R., Frevert, C.W. et al. (2003).  Fas (CD95) induces proinflammatory cytokine responses by human monocytes and monocyte-derived macrophages.  J Immunol, 170(12), 6209-16.
  4. Hernández-Rodríguez, J., Segarra, M., Vilardell, C., et al. (2004).  Tissue production of pro-inflammatory cytokines (IL-1β, TNFα, and IL-6) correlates with the intensity of the systemic inflammatory response and with corticosteroid requirements in giant-cell arteritis.  Rheumatology (Oxf.), 43(3), 294-301.
  5. Southerland, J.H., Taylor, G.W., Moss, K., et al. (2006).  Commonality in chronic inflammatory diseases: Periodontitis, diabetes, and coronary artery disease.  Periodontology 2000, 40, 130-43.
  6. Tzouvelekis, A., Pneumatikos, I, Bouros, D. (2005).  Serum biomarkers in acute respiratory distress syndrome an ailing prognosticator.  Respir Res, 6, 62.
  7. Miller, C.S., King C.P., Langub, M.C., et al. (2006).  Salivary biomarkers of existing periodontal disease: A cross-sectional study.  J Am Dent Assoc, 137(3), 322-29.
  8. Tanda, N., Ohyama, H., Yamakawa, M., et al. (1998). IL-1β and IL-6 in mouse parotid acinar cells: Characterization of synthesis, storage, and release.  Am J Physiol, 274(1 Pt1), G147-56.