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Salivary Interleukin-1 Beta

Technical Summary

Analyte Summary
Analyte: Interleukin-1 Beta
Aliases: IL-1B, IL-1 Beta, IL-1B, IL1β
Serum-Saliva Correlation: NA
Optimum Collection Volume: 50 μL*
*Add 300 µl to the total volume of all tests for liquid handling
Special Considerations
IL-1 Beta may be Flow Rate Dependent
Assay Summary
Methodology: ELISA
Sensitivity: <0.37 pg/mL
Assay Range: 3.13 pg/mL - 200 pg/mL
Assay Type: Quantitative

Collect Saliva Samples


Better results begin with better saliva collection. This collection protocol features general considerations to maximize salivary IL-1 Beta analysis. Use this analyte specific collection protocol to plan your collection methodology and sampling schemes.


Test Saliva Samples

@ Salimetrics
Salimetrics SalivaLab - Easy & Accurate
Order Code (lab): 5400.01
Transport Requirements: Ship on Dry Ice
Related Panels and Profiles: Salivary Cytokine Panel
@ Your Own Lab
Salimetrics Assay Kits - Better Results

Add DNA Analysis to My Study

Considerations for adding Salivary DNA to analyte Studies:

You can combine salivary analytes with easy, accurate, and affordable genomic testing using Salimetrics SalivaLab and the same sample that you are already collecting – no specialized saliva collection devices or additional samples are required.

Don’t know what SNPs are right for you? The SalivaLab’s DNA team specializes in genetic testing services, we recommend you Request a DNA Consult (gratis) to learn more about common considerations such as # of samples, participant ethnicity, and IRB Approval.

All DNA Services

DNA Extraction and Normalization
Single Nucleotide Polymorphism (SNP) Genotyping
VNTR & STR Analysis

References & Salivary IL-1 Beta Research

  1. Giannobile, W.V., Beikler, T., Kinney, J.S., et al. (2009).  Saliva as a diagnostic tool for periodontal disease: Current state and future directions.  Periodontology 2000, 50, 52-64.
  2. Pirhonen, J., Sareneva, R., Kurimoto, M., et al. (1999).  Virus infection activates IL-1β and IL-18 production in human macrophages by a caspase-1-dependent pathway.  J Immunol, 162(12), 7322-29.
  3. Park, D.R., Thomsen, A.R., Frevert, C.W. et al. (2003).  Fas (CD95) induces proinflammatory cytokine responses by human monocytes and monocyte-derived macrophages.  J Immunol, 170(12), 6209-16.
  4. Hernández-Rodríguez, J., Segarra, M., Vilardell, C., et al. (2004).  Tissue production of pro-inflammatory cytokines (IL-1β, TNFα, and IL-6) correlates with the intensity of the systemic inflammatory response and with corticosteroid requirements in giant-cell arteritis.  Rheumatology (Oxf.), 43(3), 294-301.
  5. Southerland, J.H., Taylor, G.W., Moss, K., et al. (2006).  Commonality in chronic inflammatory diseases: Periodontitis, diabetes, and coronary artery disease.  Periodontology 2000, 40, 130-43.
  6. Tzouvelekis, A., Pneumatikos, I, Bouros, D. (2005).  Serum biomarkers in acute respiratory distress syndrome an ailing prognosticator.  Respir Res, 6, 62.
  7. Miller, C.S., King C.P., Langub, M.C., et al. (2006).  Salivary biomarkers of existing periodontal disease: A cross-sectional study.  J Am Dent Assoc, 137(3), 322-29.
  8. Tanda, N., Ohyama, H., Yamakawa, M., et al. (1998). IL-1β and IL-6 in mouse parotid acinar cells: Characterization of synthesis, storage, and release.  Am J Physiol, 274(1 Pt1), G147-56.
Contact: Salimetrics (USA)
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Salimetrics’ COVID-19 Status – 8 April 2020 – No change to Prior Update:

Salimetrics’ Sales and Customer Service, as well as all other non-laboratory personnel, have successfully transitioned to working remote and are fully able to provide support to our customers.

Our Salimetrics Pennsylvania Manufacturing Center remains open for customer orders and shipments. All Salimetrics’ laboratory personnel are following PPE guidelines per CDC Biosafety Level 2 (BSL-2).

The Salimetrics’ SalivaLab, located in California, is open to receive samples. In accordance with State of California Executive Order N-33-20 effective March 19, 2020, our Carlsbad, California facility, including R&D and SalivaLab personnel, will remain open working on research critical to the COVID-19 response; onsite SalivaLab personnel will be able to receive samples, and in some cases, test and send data.  All Salimetrics’ laboratory personnel are following PPE guidelines per CDC Biosafety Level 2 (BSL-2).



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