Similar to IgG, since the major salivary source of IgM is blood plasma, the total amount of IgM varies over time depending on how much serum components are introduced into oral fluid and is subject to the influences of dilution by salivary flow. Therefore, when measuring pathogen specific IgM, total IgM can be used to qualify a saliva sample to assure sufficient levels of total IgM to provide confidence in pathogen specific IgM results. In this regard, total IgM may be essential to prove a negative pathogen specific test result. In addition, this assay may be used to qualify samples for testing after sample storage.
|Analyte:||Total Immunoglobulin M|
|Optimum Collection Volume:||50 μL*|
|Assay Range:||0.39 – 25 ng/mL|
Collect Saliva Samples
IgM SALIVA COLLECTION CONSIDERATIONS
Better results begin with better saliva collection. This collection protocol features general considerations to maximize salivary immunoglobulin M analysis. Use this analyte specific collection protocol to plan your collection methodology and sampling schemes.
APPROVED SALIVARY IgM COLLECTION METHODS
Add DNA Analysis to My Study
Considerations for adding Salivary DNA to analyte Studies:
You can combine salivary analytes with easy, accurate, and affordable genomic testing using Salimetrics SalivaLab and the same sample that you are already collecting – no specialized saliva collection devices or additional samples are required.
Don’t know what SNPs are right for you? The SalivaLab’s DNA team specializes in genetic testing services, we recommend you Request a DNA Consult (gratis) to learn more about common considerations such as # of samples, participant ethnicity, and IRB Approval.
All DNA Services
References & Salivary IgM Research
- Fereidan-Esfahani M, Nayfeh T, Warrington A, Howe CL, Rodriguez M. IgM Natural Autoantibodies in Physiology and the Treatment of Disease. Methods in molecular biology. 2019;1904:53-81.
- Michaud E, Mastrandrea C, Rochereau N, Paul S. Human Secretory IgM: An Elusive Player in Mucosal Immunity. Trends Immunol. 2020;41(2):141-56.
- Madar R, Straka S, Baska T. Detection of antibodies in saliva–an effective auxiliary method in surveillance of infectious diseases. Bratisl Lek Listy. 2002;103(1):38-41.
- Brandtzaeg P. Do salivary antibodies reliably reflect both mucosal and systemic immunity? Annals of the New York Academy of Sciences. 2007;1098:288-311.