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Glucocorticoid Receptor – NR3C1

Gene Summary
Gene: Glucocorticoid Receptor
Gene Symbol: NR3C1
Related Analyte(s): Insulin, Cortisol
Common SNPs
rs41423247 , rs6198
Assay Methodology
Genomic DNA, purified using silica based membrane columns is analyzed by TaqMan® SNP Genotyping Assays run on the 7900HT real time PCR system
Yield: 2-5 ug genomic DNA

Collect Saliva Samples

DNA SALIVA COLLECTION CONSIDERATIONS

Better results begin with better saliva collection. This collection protocol features general considerations to maximize salivary DNA analysis. Use this collection protocol to plan your collection methodology and sampling schemes.

APPROVED SALIVARY DNA COLLECTION METHODS

Test Saliva Samples

@ Salimetrics
Salimetrics SalivaLab - Easy & Accurate
Order Code (lab): 5811 (SNP Genotyping)
Transport Requirements: Ship on Dry Ice
@ Your Own Lab
Salimetrics Assay Kits - Better Results

The validated method used by Salimetrics is proprietary and not available in assay kit form at this time.

References & NR3C1 Related Research

  1. Turner, J. and Muller, C (2005). Structure of the glucocorticoid receptor (NR3C1) gene 5’ untranslated region: identification, and tissue distribution of multiple new human exon 1. Journal of Molecular Endocrinology. 35(2), 283-292.
  2. Teran-Garcia et al. (2007). Genetics of the metabolic syndrome. Applied Physiology, Nutrition, and Metabolism. 32(1), 89-114.
  3. McGowan, P. et al. (2009). Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. Nature Neuroscience. 12(3), 342–348.
  4. Schatzberg, A.F. et al. (2013). HPA axis genetic variation, cortisol and psychosis in major depression. Molecular Psychiatry. 19(2), 220-227.
  5. DeRijk, R. et al. (2007). Corticosteroid receptor polymorphisms: Determinants of vulnerability and resilience. European Journal of Pharmacology. 583(2-3), 303-311.
  6. Szczepankiewicz, A. et al. (2011). Glucocorticoid receptor polymorphism is associated with major depression and predominance of depression in the course of bipolar disorder. Journal of Affective Disorders. 134(1-3), 138-144.