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Glucocorticoid Receptor – NR3C1

Biomarkers

TECHNICAL SUMMARY

Gene Summary
Gene: Glucocorticoid Receptor
Gene Symbol: NR3C1
Related Analyte(s): Insulin, Cortisol
Common SNPs
rs41423247 , rs6198
Assay Methodology
Genomic DNA, purified using silica based membrane columns is analyzed by TaqMan® SNP Genotyping Assays run on the 7900HT real time PCR system
Yield: 2-5 ug genomic DNA
Biomarkers

How to collect Glucocorticoid Receptor – NR3C1

APPROVED SALIVARY DNA COLLECTION METHODS

References & NR3C1 Related Research

  1. Turner, J. and Muller, C (2005). Structure of the glucocorticoid receptor (NR3C1) gene 5’ untranslated region: identification, and tissue distribution of multiple new human exon 1. Journal of Molecular Endocrinology. 35(2), 283-292.
  2. Teran-Garcia et al. (2007). Genetics of the metabolic syndrome. Applied Physiology, Nutrition, and Metabolism. 32(1), 89-114.
  3. McGowan, P. et al. (2009). Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. Nature Neuroscience. 12(3), 342–348.
  4. Schatzberg, A.F. et al. (2013). HPA axis genetic variation, cortisol and psychosis in major depression. Molecular Psychiatry. 19(2), 220-227.
  5. DeRijk, R. et al. (2007). Corticosteroid receptor polymorphisms: Determinants of vulnerability and resilience. European Journal of Pharmacology. 583(2-3), 303-311.
  6. Szczepankiewicz, A. et al. (2011). Glucocorticoid receptor polymorphism is associated with major depression and predominance of depression in the course of bipolar disorder. Journal of Affective Disorders. 134(1-3), 138-144.

How Can we help?

Contact: Salimetrics (USA)
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