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Salivary SIgA

Technical Summary

Analyte Summary
Analyte: Secretory Immunoglobulin A
Aliases: SIgA, Secretory IgA
Serum-Saliva Correlation: NA
Optimum Collection Volume: 50 μL*
*Add 300 µl to the total volume of all tests for liquid handling
Special Considerations
SIgA is Location Dependent

SIgA is Flow Rate Dependent (μg/mL)

Passive Drool is the Recommended Collection Method
Assay Summary
Methodology: ELISA
Sensitivity: 2.5 μg/mL
Assay Range: 2.50 µg/mL – 600 µg/mL
Assay Type: Quantitative

Collect Saliva Samples


Better results begin with better saliva collection. This collection protocol features general considerations to maximize salivary ​Secretory IgA analysis. Use this analyte specific collection protocol to plan your collection methodology and sampling schemes.


Test Saliva Samples

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Salimetrics SalivaLab - Easy & Accurate
Order Code (lab): 5180
Transport Requirements: Ship on Dry Ice
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Add DNA Analysis to My Study

Considerations for adding Salivary DNA to analyte Studies:

You can combine salivary analytes with easy, accurate, and affordable genomic testing using Salimetrics SalivaLab and the same sample that you are already collecting – no specialized saliva collection devices or additional samples are required.

Don’t know what SNPs are right for you? The SalivaLab’s DNA team specializes in genetic testing services, we recommend you Request a DNA Consult (gratis) to learn more about common considerations such as # of samples, participant ethnicity, and IRB Approval.

All DNA Services

DNA Extraction and Normalization
Single Nucleotide Polymorphism (SNP) Genotyping
VNTR & STR Analysis

References & Salivary Secretory IgA Research

  1. Holmgren, J., Czerkinsky, C. (2005).  Mucosal immunity and vaccines.  Nature Medicine, 11(4 Suppl), s45-53.
  2. Brandtzaeg, P. (2007). Do salivary antibodies reliably reflect both mucosal and systemic immunity? Ann N Y Acad Sci, 1098, 288-311.
  3. Crawford, J.M., Taubman, M.A., Smith D.J. (1975).  Minor salivary glands as a major source of secretory immunoglobulin A in the human oral cavity.  Science, 190(4220), 1206-9.
  4. Li, T.-L., Gleeson, M. (2004). The effect of single and repeated bouts of prolonged cycling and circadian variation on saliva flow rate, immunoglobulin A and alpha-amylase responses.  J Sports Sci, 22(11-12), 1015-1024.
  5. Tsujita, S., Morimoto, K. (1999).  Secretory IgA in saliva can be a useful stress marker. Env Health Prev Med, 4, 1-8.
  6. Bishop, N.C., Gleeson, M. (2009).  Acute and chronic effects of exercise on markers of mucosal immunity. Front Biosci, 1(14), 4444-56.
Contact: Salimetrics (USA)
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Salimetrics’ COVID-19 Status – 6 April 2020 – No change to Prior Update:

Salimetrics’ Sales and Customer Service, as well as all other non-laboratory personnel, have successfully transitioned to working remote and are fully able to provide support to our customers.

Our Salimetrics Pennsylvania Manufacturing Center remains open for customer orders and shipments. All Salimetrics’ laboratory personnel are following PPE guidelines per CDC Biosafety Level 2 (BSL-2).

The Salimetrics’ SalivaLab, located in California, is open to receive samples. In accordance with State of California Executive Order N-33-20 effective March 19, 2020, our Carlsbad, California facility, including R&D and SalivaLab personnel, will remain open working on research critical to the COVID-19 response; onsite SalivaLab personnel will be able to receive samples, and in some cases, test and send data.  All Salimetrics’ laboratory personnel are following PPE guidelines per CDC Biosafety Level 2 (BSL-2).



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