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Salivary SIgA

Technical Summary

Analyte Summary
Analyte: Secretory Immunoglobulin A
Aliases: SIgA, Secretory IgA
Serum-Saliva Correlation: NA
Optimum Collection Volume: 50 μL*
*Add 300 µl to the total volume of all tests for liquid handling
Special Considerations
SIgA is Location Dependent

SIgA is Flow Rate Dependent (μg/mL)

Passive Drool is the Recommended Collection Method
Assay Summary
Methodology: ELISA
Sensitivity: 2.5 μg/mL
Assay Range: 2.50 µg/mL – 600 µg/mL
Assay Type: Quantitative

Collect Saliva Samples


Better results begin with better saliva collection. This collection protocol features general considerations to maximize salivary ​Secretory IgA analysis. Use this analyte specific collection protocol to plan your collection methodology and sampling schemes.


Test Saliva Samples

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Order Code (lab): 5180
Transport Requirements: Ship on Dry Ice
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Add DNA Analysis to My Study

Considerations for adding Salivary DNA to analyte Studies:

You can combine salivary analytes with easy, accurate, and affordable genomic testing using Salimetrics SalivaLab and the same sample that you are already collecting – no specialized saliva collection devices or additional samples are required.

Don’t know what SNPs are right for you? The SalivaLab’s DNA team specializes in genetic testing services, we recommend you Request a DNA Consult (gratis) to learn more about common considerations such as # of samples, participant ethnicity, and IRB Approval.

All DNA Services

DNA Extraction and Normalization
Single Nucleotide Polymorphism (SNP) Genotyping
VNTR & STR Analysis

References & Salivary Secretory IgA Research

  1. Holmgren, J., Czerkinsky, C. (2005).  Mucosal immunity and vaccines.  Nature Medicine, 11(4 Suppl), s45-53.
  2. Brandtzaeg, P. (2007). Do salivary antibodies reliably reflect both mucosal and systemic immunity? Ann N Y Acad Sci, 1098, 288-311.
  3. Crawford, J.M., Taubman, M.A., Smith D.J. (1975).  Minor salivary glands as a major source of secretory immunoglobulin A in the human oral cavity.  Science, 190(4220), 1206-9.
  4. Li, T.-L., Gleeson, M. (2004). The effect of single and repeated bouts of prolonged cycling and circadian variation on saliva flow rate, immunoglobulin A and alpha-amylase responses.  J Sports Sci, 22(11-12), 1015-1024.
  5. Tsujita, S., Morimoto, K. (1999).  Secretory IgA in saliva can be a useful stress marker. Env Health Prev Med, 4, 1-8.
  6. Bishop, N.C., Gleeson, M. (2009).  Acute and chronic effects of exercise on markers of mucosal immunity. Front Biosci, 1(14), 4444-56.
Contact: Salimetrics (USA)
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