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Cholinergic Receptor, Nicotinic Alpha 3 Gene – CHRNA3

Biomarkers

TECHNICAL SUMMARY

Gene Summary
Gene: Cholinergic Receptor, Nicotinic Alpha 3
Gene Symbol: CHRNA3
Related Analyte(s): Cotinine, Cortisol
Common SNPs
rs1051730 , rs6495309
Assay Methodology
Genomic DNA, purified using silica based membrane columns is analyzed by TaqMan® SNP Genotyping Assays run on the 7900HT real time PCR system
Yield: 2-5 ug genomic DNA
Biomarkers

How to collect Cholinergic Receptor, Nicotinic Alpha 3 Gene – CHRNA3

APPROVED SALIVARY DNA COLLECTION METHODS

References & CHRNA3 Related Research

  1. CHRNA3 cholinergic receptor nicotinic alpha 3 on NCBI
  2. Thorgeirsson, TE. et al. (2008). A variant associated with nicotine dependence, lung cancer and peripheral arterial disease. Nature. 452(7187), 638-642.
  3. Pillai, S. et al. (2009). A Genome-Wide Association Study in Chronic Obstructive Pulmonary Disease (COPD): Identification of Two Major Susceptibility Loci. PLOS Genetics. 5(3), e1000421.
  4. Cui, K. et al. (2014). Four SNPs in the CHRNA3/5 alpha-neuronal nicotinic acetylcholine receptor subunit locus are associated with COPD risk based on meta-analyses. PLOS ONE. 9(7), e102324.
  5. Zhang, J. et al. (2011). Nicotinic acetylcholine receptor variants associated with susceptibility to chronic obstructive pulmonary disease: a meta-analysis. Respiratory Research. 12(1), 158.
  6. Yang, L. et al. (2012). Functional Polymorphisms of CHRNA3 Predict Risks of Chronic Obstructive Pulmonary Disease and Lung Cancer in Chinese. PLOS ONE. 7(10):e46071.

How Can we help?

Contact: Salimetrics (USA)
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