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Cholinergic Receptor, Nicotinic Alpha 3 Gene – CHRNA3

Gene Summary
Gene: Cholinergic Receptor, Nicotinic Alpha 3
Gene Symbol: CHRNA3
Related Analyte(s): Cotinine, Cortisol
Common SNPs
rs1051730 , rs6495309
Assay Methodology
Genomic DNA, purified using silica based membrane columns is analyzed by TaqMan® SNP Genotyping Assays run on the 7900HT real time PCR system
Yield: 2-5 ug genomic DNA

Collect Saliva Samples

DNA SALIVA COLLECTION CONSIDERATIONS

Better results begin with better saliva collection. This collection protocol features general considerations to maximize salivary DNA analysis. Use this collection protocol to plan your collection methodology and sampling schemes.

APPROVED SALIVARY DNA COLLECTION METHODS

Test Saliva Samples

@ Salimetrics
Salimetrics SalivaLab - Easy & Accurate
Order Code (lab): 5811 (SNP Genotyping)
Transport Requirements: Ship on Dry Ice
@ Your Own Lab
Salimetrics Assay Kits - Better Results

The validated method used by Salimetrics is proprietary and not available in assay kit form at this time.

References & CHRNA3 Related Research

  1. CHRNA3 cholinergic receptor nicotinic alpha 3 on NCBI
  2. Thorgeirsson, TE. et al. (2008). A variant associated with nicotine dependence, lung cancer and peripheral arterial disease. Nature. 452(7187), 638-642.
  3. Pillai, S. et al. (2009). A Genome-Wide Association Study in Chronic Obstructive Pulmonary Disease (COPD): Identification of Two Major Susceptibility Loci. PLOS Genetics. 5(3), e1000421.
  4. Cui, K. et al. (2014). Four SNPs in the CHRNA3/5 alpha-neuronal nicotinic acetylcholine receptor subunit locus are associated with COPD risk based on meta-analyses. PLOS ONE. 9(7), e102324.
  5. Zhang, J. et al. (2011). Nicotinic acetylcholine receptor variants associated with susceptibility to chronic obstructive pulmonary disease: a meta-analysis. Respiratory Research. 12(1), 158.
  6. Yang, L. et al. (2012). Functional Polymorphisms of CHRNA3 Predict Risks of Chronic Obstructive Pulmonary Disease and Lung Cancer in Chinese. PLOS ONE. 7(10):e46071.