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Salivary DHEA-S

Technical Summary

Analyte Summary
Analyte: ​DHEA-S
Aliases: Dehydroepiandrosterone sulfate, DHEA sulfate
Serum-Saliva Correlation: NA
Optimum Collection Volume: 225 μL*
*Add 300 µl to the total volume of all tests for liquid handling
Special Considerations
DHEA-S is Flow Rate Dependent (pg/mL)
Assay Summary
Methodology: ELISA
Sensitivity: 43 pg/mL
Assay Range: 188.9 pg/mL- 15,300 pg/mL
Assay Type: Quantitative

Collect Saliva Samples


Better results begin with better saliva collection. This collection protocol features general considerations to maximize salivary DHEA-S analysis. Use this analyte specific collection protocol to plan your collection methodology and sampling schemes.


Test Saliva Samples

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Order Code (lab): 5130
Transport Requirements: Ship on Dry Ice
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Add DNA Analysis to My Study

Considerations for adding Salivary DNA to analyte Studies:

You can combine salivary analytes with easy, accurate, and affordable genomic testing using Salimetrics SalivaLab and the same sample that you are already collecting – no specialized saliva collection devices or additional samples are required.

Don’t know what SNPs are right for you? The SalivaLab’s DNA team specializes in genetic testing services, we recommend you Request a DNA Consult (gratis) to learn more about common considerations such as # of samples, participant ethnicity, and IRB Approval.

All DNA Services

DNA Extraction and Normalization
Single Nucleotide Polymorphism (SNP) Genotyping
VNTR & STR Analysis

References & Salivary DHEA-S Research

    1. Summarized in Whetzel, C.A., Klein, L.C. Measuring DHEA-S in saliva: Time of day differences and positive correlations between two different types of collection methods.  BMC Res Notes, 3:204.
    2. Krobath, P.D., Salek, F.S., Pittenger, A.L. et al. (1999).  DHEA and DHEA-S: A review.  J Clin Pharmacol 39(4), 327-48.
    3. Rosenfeld, R.S., Rosenberg, B.J., Fukushima, D.K., Hellman, L. (1975).  24-Hour secretory pattern of dehydroisoandrosterone and dehydroisoandrosterone sulfate.  J Clin Endocrinol Metab, 40(5), 850-55.
    4. Carlström, K., Karlsson, R., Von Schoultz, B. (2002).  Diurnal rhythm and effects of oral contraceptives on serum dehydroepiandrosterone sulfate (DHEAS) are related to alterations in serum albumin rather than to changes in adrenocortical steroid secretion.  Scan J Clin Lab Invest, 62(5), 361-68.
    5. Labrie, F., Bélanger, A., Cusan, L., Candas, B. (1997).  Physiological changes in dehydroepiandrosterone are not reflected by serum levels of active androgens and estrogens but of their metabolites: Intracrinology.  J Clin Endocrinol Metab, 82(8), 2403-9.
    6. Labrie, F., Luu-The, V. Bélanger, A., et al. (2005).  Is dehydroepiandrosterone a hormone? J Endocrinol, 187, 169-96.
    7. Charalampopoulos, I., Alexaki, V.-I., Tsatsanis, C., et al. (2006).  Neurosteroids as endogenous inhibitors of neuronal cell apoptosis in aging.  Ann N Y Acad Science, 1088, 138-52.
    8. Baulieu, E.-E., Robel, P. (1998). Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) as neuroactive neurosteroids.  Proc Natl Acad Sci U S A, 95(8), 4089-91.)
    9. Kellner, M., Muhtz, C., Peter, F., et al. (2010).  Increased DHEA and DHEA-S plasma levels in patients with post-traumatic stress disorder and a history of childhood abuse. J Psychiatr Res, 44(4), 215-9.
    10. Golubchik, P., Mozes, T., Maayan, R., Weizman, A. (2009).  Neurosteroid blood levels in delinquent adolescent boys with conduct disorder. Eur Neuropsychopharmacol, 19(1), 49-52.

    1. Azurmendi, A., Braza, F., Garcia, F. et al. (2006). Aggression, dominance and affiliation: Their relationships with androgen levels and intelligence in 5-year-old children. Horm Behav, 50(1), 132-40.
    2. MacLaughlin, B.W., Wang, D., Noone, A.-M., et al. (2010).  Stress biomarkers in medical students participating in a mind body medicine skills program.  eCAM, doi:10.1093/ecam/neq039.
    3. Wang, J.-S., Chen, S.-M., Lee, S.-P., et al. 2009).  Dehydroepiandrosterone sulfate linked to physiologic response against hot spring immersion. Steroids, 74(12), 945-49.
    4. Vining, R.F., McGinley, R.A., Symons, R.G. (1983).  Hormones in saliva: Mode of entry and consequent implications for clinical interpretation.  Clin Chem, 29(10), 1752-56.
    5. Konttinen, Y.T., Stegaev, V., Mackiewicz, Z., et al. (2010).  Salivary glands — ‘an unisex organ’? Oral Dis, 16(7), 577-85.
    6. Pomari, E., Nardi, A., Fiore, C., et al. (2009).  Transcriptional control of human organic anion transporting polypeptide 2B1 gene.  J Steroid Biochem Mol Biol, 115(3-5), 146-52.
    7. Jezova, D., Hlavacova, N. (2008). Endocrine factors in stress and psychiatric disorders: Focus on anxiety and salivary steroids.  Ann N Y Acad Sci, 1148, 495-503.

Contact: Salimetrics (USA)
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Salimetrics’ COVID-19 Status – 8 April 2020 – No change to Prior Update:

Salimetrics’ Sales and Customer Service, as well as all other non-laboratory personnel, have successfully transitioned to working remote and are fully able to provide support to our customers.

Our Salimetrics Pennsylvania Manufacturing Center remains open for customer orders and shipments. All Salimetrics’ laboratory personnel are following PPE guidelines per CDC Biosafety Level 2 (BSL-2).

The Salimetrics’ SalivaLab, located in California, is open to receive samples. In accordance with State of California Executive Order N-33-20 effective March 19, 2020, our Carlsbad, California facility, including R&D and SalivaLab personnel, will remain open working on research critical to the COVID-19 response; onsite SalivaLab personnel will be able to receive samples, and in some cases, test and send data.  All Salimetrics’ laboratory personnel are following PPE guidelines per CDC Biosafety Level 2 (BSL-2).



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