MRs are abundantly expressed in the hippocampus as well as the prefrontal cortex, areas within the brain that are critical for memory and executive function. MRs have also been shown to specifically signal aldosterone, which in turn regulates sodium and water retention throughout the body (2). Towards this function, MRs can be found in both epithelial (e.g. kidney, colon) and non-epithelial tissues (e.g. heart, brain) (2, 3).
Interestingly, multiple MR variants or SNPs have been implicated in the growing research of cognitive abilities, mood, and depression. For instance, DeRijk et al identified MR variants that may contribute to individual differences in resiliency and vulnerability to certain stressors, which is a huge step toward targeted treatments in both homeostasis and health recovery (4). Gender dependent effects have also been observed with MR variants for depression susceptibility following childhood maltreatment (5). For more research and details on MR SNPs, visit MR on SNPedia.
When interpreting data from your current study or planning for the future, consider the polymorphisms that influence stress responses. For a complete list of SNPs available for research, we recommend contacting one of our experts for guidance on the most relevant selections for your research.
|Gene Symbol:||MR,MLR, or MCR|
|Also Known As:||NR3C2|
|Genomic DNA, purified using silica based membrane columns is analyzed by TaqMan® SNP Genotyping Assays run on the 7900HT real time PCR system
Yield: 2-5 ug genomic DNA
Collect Saliva Samples
DNA SALIVA COLLECTION CONSIDERATIONS
Better results begin with better saliva collection. This collection protocol features general considerations to maximize salivary DNA analysis. Use this collection protocol to plan your collection methodology and sampling schemes.
Test Saliva Samples
|Order Code (lab):||5811 (SNP Genotyping)|
|Transport Requirements:||Ship on Dry Ice|
The validated method used by Salimetrics is proprietary and not available in assay kit form at this time.
References & MR Related Research
- Kellendonk, C. et al (2002). Corticosteroid receptors in the brain: gene targeting studies. Brain Research Bulletin. 57(1), 73-83
- Rogerson, FM. et al (2003). Dissecting mineralocorticoid receptor structure and function. Journal of Steroid Biochemistry & Molecular Biology. 85(2-5), 389-396.
- Funder, JW. Et al (2005). Mineralocorticoid receptors: distribution and activation. Heart Failure Reviews. 10(1), 15-22
- DeRijk, R. et al (2005). Corticosteroid receptor genetic polymorphisms and stress responsivity. Endocrine. 28(3), 263-270.
- Vinkers, CH. Et al (2015). Mineralocorticoid receptor haplotypes sex-dependently moderate depression susceptibility following childhood maltreatment. Psychoneuroendocrinology. 54, 90-102.