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Mineralocorticoid Receptor – MR, NR3C2

Gene Summary
Gene: Mineralocorticoid Receptor
Gene Symbol: MR,MLR, or MCR
Also Known As: NR3C2
Related Analyte(s): Cortisol
Assay Methodology
Genomic DNA, purified using silica based membrane columns is analyzed by TaqMan® SNP Genotyping Assays run on the 7900HT real time PCR system
Yield: 2-5 ug genomic DNA

Collect Saliva Samples

DNA SALIVA COLLECTION CONSIDERATIONS

Better results begin with better saliva collection. This collection protocol features general considerations to maximize salivary DNA analysis. Use this collection protocol to plan your collection methodology and sampling schemes.

APPROVED SALIVARY DNA COLLECTION METHODS

Test Saliva Samples

@ Salimetrics
Salimetrics SalivaLab - Easy & Accurate
Order Code (lab): 5811 (SNP Genotyping)
Transport Requirements: Ship on Dry Ice
@ Your Own Lab
Salimetrics Assay Kits - Better Results

The validated method used by Salimetrics is proprietary and not available in assay kit form at this time.

References & MR Related Research

  1. Kellendonk, C. et al (2002). Corticosteroid receptors in the brain: gene targeting studies. Brain Research Bulletin. 57(1), 73-83
  2. Rogerson, FM. et al (2003). Dissecting mineralocorticoid receptor structure and function. Journal of Steroid Biochemistry & Molecular Biology. 85(2-5), 389-396.
  3. Funder, JW. Et al (2005). Mineralocorticoid receptors: distribution and activation. Heart Failure Reviews. 10(1), 15-22
  4. DeRijk, R. et al (2005). Corticosteroid receptor genetic polymorphisms and stress responsivity. Endocrine. 28(3), 263-270.
  5. Vinkers, CH. Et al (2015). Mineralocorticoid receptor haplotypes sex-dependently moderate depression susceptibility following childhood maltreatment. Psychoneuroendocrinology. 54, 90-102.