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Brain-Derived Neurotrophic Factor – BDNF

Biomarkers

TECHNICAL SUMMARY

Gene Summary
Gene: Brain-Derived Neurotrophic Factor
Gene Symbol: BDNF
Related Analyte(s): Cortisol
Common SNPs
rs6265 , rs12291063 , C270T , rs7103411 , rs2030324
Assay Methodology
Genomic DNA, purified using silica based membrane columns is analyzed by TaqMan® SNP Genotyping Assays run on the 7900HT real time PCR system
Yield: 2-5 ug genomic DNA
Biomarkers

How to collect Brain-Derived Neurotrophic Factor – BDNF

APPROVED SALIVARY DNA COLLECTION METHODS

References & BDNF Related Research

  1. Molendijk, ML. et al. (2013). Serum BDNF concentrations as peripheral manifestations of depression: evidence from a systematic review and meta-analyses on 179 associations (N=9484). Molecular Psychiatry. 19(7), 791-800.
  2. Fernandes, BS. et al. (2013). Decreased peripheral brain-derived neurotrophic factor levels are a biomarker of disease activity in major psychiatric disorders: a comparative meta-analysis. Molecular Psychiatry. 19(7), 750-751.
  3. Green, MJ. et al. (2011). Brain-derived neurotrophic factor levels in schizophrenia: a systematic review with meta-analysis. Molecular Psychiatry. 16(9), 960-972.
  4. Petryshen, TL. et al. (2010). Population genetic study of the brain-derived neurotrophic factor (BDNF) gene. Molecular Psychiatry. 15(8), 810-815.
  5. Armbruster, D. et al. (2015). BDNF val66met genotype shows distinct associations with the acoustic startle reflex and the cortisol stress response in young adults and children. Psychoneuroendocrinology. 66(2015), 39-46.
  6. Mou, Z. et al. (2015). Human Obesity Associated with an Intronic SNP in the Brain-Derived Neurotrophic Factor Locus. Cell Reports. 13(6), 1073-1080.

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Contact: Salimetrics (USA)
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