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Brain-Derived Neurotrophic Factor – BDNF

Gene Summary
Gene: Brain-Derived Neurotrophic Factor
Gene Symbol: BDNF
Related Analyte(s): Cortisol
Common SNPs
rs6265 , rs12291063 , C270T , rs7103411 , rs2030324
Assay Methodology
Genomic DNA, purified using silica based membrane columns is analyzed by TaqMan® SNP Genotyping Assays run on the 7900HT real time PCR system
Yield: 2-5 ug genomic DNA

Collect Saliva Samples

DNA SALIVA COLLECTION CONSIDERATIONS

Better results begin with better saliva collection. This collection protocol features general considerations to maximize salivary DNA analysis. Use this collection protocol to plan your collection methodology and sampling schemes.

APPROVED SALIVARY DNA COLLECTION METHODS

Test Saliva Samples

@ Salimetrics
Salimetrics SalivaLab - Easy & Accurate
Order Code (lab): 5811 (SNP Genotyping)
Transport Requirements: Ship on Dry Ice
@ Your Own Lab
Salimetrics Assay Kits - Better Results

The validated method used by Salimetrics is proprietary and not available in assay kit form at this time.

References & BDNF Related Research

  1. Molendijk, ML. et al. (2013). Serum BDNF concentrations as peripheral manifestations of depression: evidence from a systematic review and meta-analyses on 179 associations (N=9484). Molecular Psychiatry. 19(7), 791-800.
  2. Fernandes, BS. et al. (2013). Decreased peripheral brain-derived neurotrophic factor levels are a biomarker of disease activity in major psychiatric disorders: a comparative meta-analysis. Molecular Psychiatry. 19(7), 750-751.
  3. Green, MJ. et al. (2011). Brain-derived neurotrophic factor levels in schizophrenia: a systematic review with meta-analysis. Molecular Psychiatry. 16(9), 960-972.
  4. Petryshen, TL. et al. (2010). Population genetic study of the brain-derived neurotrophic factor (BDNF) gene. Molecular Psychiatry. 15(8), 810-815.
  5. Armbruster, D. et al. (2015). BDNF val66met genotype shows distinct associations with the acoustic startle reflex and the cortisol stress response in young adults and children. Psychoneuroendocrinology. 66(2015), 39-46.
  6. Mou, Z. et al. (2015). Human Obesity Associated with an Intronic SNP in the Brain-Derived Neurotrophic Factor Locus. Cell Reports. 13(6), 1073-1080.