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Salivary Aldosterone

Technical Summary

Analyte Summary:
Analyte: Aldosterone
Aliases: NA
Serum-Saliva Correlation: 0.75-0.96
Optimum Collection Volume: 175 μL*
*Add 300 µl to the total volume of all tests for liquid handling
Interfering Factors
Posture affects aldosterone levels - we recommend sampling after 30 minutes in position.

Licorice (real) mimics aldosterone and should be avoided 2 weeks before collection.
Assay Summary:
Methodology: ELISA
Sensitivity: 35 pg/mL
Assay Range: ----
Assay Type: Quantitative

Collect Saliva Samples

SALIVARY ALDOSTERONE SALIVA COLLECTION CONSIDERATIONS

Better results begin with better analyte collection. This collection protocol features general considerations to maximize salivary Aldosterone analysis. Use this analyte-specific collection protocol to plan your collection methodology and sampling schemes.

APPROVED SALIVARY ALDOSTERONE COLLECTION METHODS

Test Saliva Samples

@ Salimetrics
Salimetrics SalivaLab - Easy & Accurate
Order Code (lab): 5108
Transport Requirements: Ship on Dry Ice
@ Your Own Lab
Salimetrics Assay Kits - Better Results

The validated method used by Salimetrics is proprietary and not available in assay kit form at this time.

Add DNA Analysis to My Study

Considerations for adding Salivary DNA to analyte Studies:

You can combine salivary analytes with easy, accurate, and affordable genomic testing using Salimetrics SalivaLab and the same sample that you are already collecting – no specialized saliva collection devices or additional samples are required.

Don’t know what SNPs are right for you? The SalivaLab’s DNA team specializes in genetic testing services, we recommend you Request a DNA Consult (gratis) to learn more about common considerations such as # of samples, participant ethnicity, and IRB Approval.

All DNA Services

DNA Extraction and Normalization
Single Nucleotide Polymorphism (SNP) Genotyping
VNTR & STR Analysis

References & Salivary Aldosterone Research

    1. Pilz, S., Tomaschitz, A., Stepan, V., Obermayer-Pietsch, B., Fahrleitner-Pammer, A., Schweighofer, N., Portugaller, H.R., et al. (2009). Graz Endocrine Causes of Hypertension (GECOH) study: A diagnostic accuracy study of aldosterone to active renin ratio in screening for primary aldosteronism. BMC Endocr Disord, 9:11.
    2. Manolopoulou, J., Gerum, S., Mulatero, P., Rossignol, P., Plouin, P.F., Reincke, M., & Bidlingmaier, M. (2010). Salivary aldosterone as a diagnostic aid in primary aldosteronism. Horm Metab Res, 42(6), 400-5.
    3. Jezova, D. & Hlavacova, N. (2008). Endocrine factors in stress and psychiatric disorders. Ann N Y Acad Sci, 1148, 495-503.
    4. Williams, G.H. (2005). Aldosterone biosynthesis, regulation, and classical mechanism of action. Heart Fail Rev, 10(1), 7-13.
    5. Meneton, P., Loffing, J., & Warnock, D.G. (2004). Sodium and potassium handling by the aldosterone-sensitive distal nephron: The pivotal role of the distal and connecting tubule. Am J Physiol Renal Physiol, 287(4), F593-601.
    6. Vogt, B. & Burnier, M. (2009). Aldosterone and cardiovascular risk. Curr Hypertens Rep, 11(6), 450-55.
    7. Schrier, R.W., Masoumi, A., & Elhassan, E. (2010). Aldosterone: Role in edematous disorders, hypertension, chronic renal failure, and metabolic syndrome. Clin J Am Soc Nephrol, 5(6), 1132-40.
    8. Whaley-Connell, A., Johnson, M.S., & Sowers, J.R. (2010). Aldosterone: Role in the cardiometabolic syndrome and resistant hypertension. Prog Cardiovasc Dis, 52(5), 401-9.
    9. Vining, R.F., McGinley, R.A., Symons, R.G. (1983). Hormones in saliva: Mode of entry and consequent implications for clinical interpretation. Clin Chem, 29(10), 1752-56.
    10. Manolopoulou, J., Mulatero, P., Maser-Gluth, C., Rossignol, P., Spyroglou, A., Vakrilova, Y., Petersenn, S., et al. (2009). Saliva as a medium for aldosterone measurement in repeated sampling studies. Steroids, 74(10-11), 853-58.

    1. Vining, R.F., McGinley, R.A. (1987). The measurement of hormones in saliva: Possibilities and pitfalls. J Steroid Biochem, 27(1-3), 81-94.

Contact: Salimetrics (USA)
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Salimetrics’ COVID-19 Status – 6 April 2020 – No change to Prior Update:

Salimetrics’ Sales and Customer Service, as well as all other non-laboratory personnel, have successfully transitioned to working remote and are fully able to provide support to our customers.

Our Salimetrics Pennsylvania Manufacturing Center remains open for customer orders and shipments. All Salimetrics’ laboratory personnel are following PPE guidelines per CDC Biosafety Level 2 (BSL-2).

The Salimetrics’ SalivaLab, located in California, is open to receive samples. In accordance with State of California Executive Order N-33-20 effective March 19, 2020, our Carlsbad, California facility, including R&D and SalivaLab personnel, will remain open working on research critical to the COVID-19 response; onsite SalivaLab personnel will be able to receive samples, and in some cases, test and send data.  All Salimetrics’ laboratory personnel are following PPE guidelines per CDC Biosafety Level 2 (BSL-2).

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