It appears that your browser may be outdated and performance may be limited. The My Study builder is best viewed with the latest internet browsers. However, if you’d prefer to use our standard form, you can access it below.

Go to Internet Explorer Quick Quote Form

Dismiss this message

Salivary Interferon Gamma

Salivary Cytokines Quick Start Research Guide

Download the de facto guide for grant applications, summaries, and research studies.

Need Help?

Ask an expert
Biomarkers

1. How to collect Salivary Interferon Gamma

APPROVED SALIVARY CYTOKINE COLLECTION METHODS

Passive Drool Saliva Collection Kit

SalivaBio Passive Drool Method

Use With: Adults, Children 6+

Salivary ​Cytokine Collection Protocol

Collection volume, general considerations, and basic guidelines to maximize salivary ​Cytokine sample integrity. Use this analyte-specific collection protocol to plan you collection methodology and sampling schemes.

Biomarkers

2. How to Assay for Salivary IFN-gamma

Easy and accurate results from the most trusted Salivary Bioscience Laboratory.

All Lab Services

Order Code5209

Biomarkers

3. Technical Summary

Analyte Summary
Analyte: Interferon Gamma
Aliases: IFN-γ, IFN-gamma
Serum-Saliva Correlation: NA
Optimum Collection Volume: 100 μL
Assay Summary
Methodology: ECL
Sensitivity: 0.37 pg/mL
Assay Range: 0.37 – 4760 pg/mL
Assay Type: Quantitative

Background

*Available as part of the Salimetrics Cytokine Panel - Not available as an individual test*

Human interferon gamma (IFN-γ, IFN-gamma) is mainly produced by lymphocytes as a glycosylated 19.3 kilo Dalton (kDa) cytokine that exists as a non-covalently linked homodimer. In general, IFN-gamma is a central regulator of innate and adaptive immune responses mounted against viral infection, mediates cell mediated immunity such as anti-tumor immune responses and is a hallmark of T helper type 1 (Th1) immune responses (1,2). In this capacity, IFN-gamma is a potent activator of macrophages and induces Class I and Class II MHC (major histocompatibility complex) expression. When IFN-gamma is expressed by Th1 lymphocytes, it polarizes the T cell response towards Th1 in a positive feedback loop by inducing Th1 differentiation from Th0 cells, while suppressing Th2 differentiation. Measurements of IFN-gamma can be used to identify T-cell driven pathology. Dysregulation of IFN-gamma is associated with a number of disorders including autoimmune diseases, Huntington’s disease and IFN-gamma levels are increased during hepatitis C infection and Tuberculosis (3). IFN-gamma may also be used as a general indicator of active viral infection. Since IFN-gamma is elevated during stress induced reactivation of herpes virus family members, such as Herpes Simplex Virus 1 (HSV1) or Epstein Barr Virus (EBV), it is possible that levels of salivary IFN-gamma may be used as a marker for stress related immune suppression. This use of IFN-gamma as a surrogate for stress induced immune suppression is an area of research that may add to others, such as cortisol, in the stress field of study.

References & Salivary IFN-gamma Research

  1. Kak G, Raza M, Tiwari BK. Interferon-gamma (IFN-gamma): Exploring its implications in infectious diseases. Biomol Concepts. 2018;9(1):64-79.
  2. Ivashkiv LB. IFNgamma: signalling, epigenetics and roles in immunity, metabolism, disease and cancer immunotherapy. Nat Rev Immunol. 2018;18(9):545-58.
  3. MacLean E, Broger T, Yerlikaya S, Fernandez-Carballo BL, Pai M, Denkinger CM. A systematic review of biomarkers to detect active tuberculosis. Nat Microbiol. 2019;4(5):748-58.
  4. Rajendran P, Chen YF, Chen YF, Chung LC, Tamilselvi S, Shen CY, et al. The multifaceted link between inflammation and human diseases. Journal of cellular physiology. 2018;233(9):6458-71.
  5. Val M, Sidoti Pinto GA, Manini L, Gandolfo S, Pentenero M. Variations of salivary concentration of cytokines and chemokines in presence of oral squamous cell carcinoma. A case-crossover longitudinal prospective study. Cytokine. 2019;120:62-5.
  6. Wang X, Kaczor-Urbanowicz KE, Wong DT. Salivary biomarkers in cancer detection. Med Oncol. 2017;34(1):7.
  7. Huck O, Buduneli N, Bravo D. Inflammatory Mediators in Periodontal Pathogenesis. Mediators Inflamm. 2019;2019:2610184.
  8. Silva N, Abusleme L, Bravo D, Dutzan N, Garcia-Sesnich J, Vernal R, et al. Host response mechanisms in periodontal diseases. J Appl Oral Sci. 2015;23(3):329-55.
  9. Gaba FI, Sheth CC, Veses V. Salivary biomarkers and their efficacies as diagnostic tools for Oral Squamous Cell Carcinoma: Systematic review and meta-analysis. J Oral Pathol Med. 2018.
  10. Slavish DC, Graham-Engeland JE, Smyth JM, Engeland CG. Salivary markers of inflammation in response to acute stress. Brain, behavior, and immunity. 2015;44:253-69.</li
  11. Sheth CC, Lopez-Pedrajas RM, Jovani-Sancho MDM, et al. Modulation of salivary cytokines in response to alcohol, tobacco and caffeine consumption: a pilot study. Sci Rep. 2018;8(1):16687.

How Can we help?

Contact: Salimetrics (USA)
View All International Distributors

NEW – Salivary Bioscience Webinars

Learn the better methods for getting the most out of your Salivary Bioscience research study.

Check Available Dates

CALL 800.790.2258
ASK AN EXPERT   REQUEST A QUOTE

X
Training Workshops