It appears that your browser may be outdated and performance may be limited. The My Study builder is best viewed with the latest internet browsers. However, if you’d prefer to use our standard form, you can access it below.

Go to Internet Explorer Quick Quote Form

Dismiss this message

Salivary ​Interleukin-7

Salivary Cytokines Quick Start Research Guide

Download the de facto guide for grant applications, summaries, and research studies.

Need Help?

Ask an expert
Biomarkers

1. How to collect Salivary ​Interleukin-7

APPROVED SALIVARY CYTOKINE COLLECTION METHODS

Passive Drool Saliva Collection Kit

SalivaBio Passive Drool Method

Use With: Adults, Children 6+

Salivary Cytokine Collection Protocol

Collection volume, general considerations, and basic guidelines to maximize salivary IL-7 sample integrity. Use this analyte-specific collection protocol to plan you collection methodology and sampling schemes.

Biomarkers

2. How to Assay for Salivary Interleukin-7

Easy and accurate results from the most trusted Salivary Bioscience Laboratory.

All Lab Services

Order Code5209

Biomarkers

3. Technical Summary

Analyte Summary
Analyte: Interleukin-7
Aliases: IL-7
Serum-Saliva Correlation: NA
Optimum Collection Volume: 100 μL
Assay Summary
Methodology: ECL
Sensitivity: 0.16 pg/mL
Assay Range: 0.16 – 563 pg/mL
Assay Type: Quantitative

Background

Human Interleukin 7 (IL-7) activity is important for every stage of T cell development and survival of naïve T cells and generation and maintenance of CD4 and CD8 T cell memory. It is also important for the formation of lymphoid structure and defense mechanisms mediated by lymphoid cells. Pathologies associated with IL-7 are those mediated by the dysregulation of lymphoid function leading to autoimmune diseases such as diabetes and multiple sclerosis, (1) and chronic inflammatory diseases, including rheumatoid arthritis and inflammatory bowel disease (2). IL-7 signaling is also associated with several types of lymphoid leukemias (3). IL-7 is a glycosylated 25 kDa hematopoietic growth factor that plays a central regulatory role throughout the lymphoid system (3).

References & Salivary IL-7 Research

  1. Lee LF, Logronio K, Tu GH, Zhai W, Ni I, Mei L, et al. (2012). Anti-IL-7 receptor-alpha reverses established type 1 diabetes in nonobese diabetic mice by modulating effector T-cell function. Proceedings of the National Academy of Sciences of the United States of America. 109(31):12674-9.
  2. Belarif L, Danger R, Kermarrec L, Nerriere-Daguin V, Pengam S, Durand T, et al. (2019). IL-7 receptor influences anti-TNF responsiveness and T cell gut homing in inflammatory bowel disease. J Clin Invest. 129(5):1910-25.
  3. Barata JT, Durum SK, Seddon B. (2019). Flip the coin: IL-7 and IL-7R in health and disease. Nat Immunol. 20(12):1584-93.

How Can we help?

Contact: Salimetrics (USA)
View All International Distributors

NEW – Salivary Bioscience Webinars

Learn the better methods for getting the most out of your Salivary Bioscience research study.

Check Available Dates

CALL 800.790.2258
ASK AN EXPERT   REQUEST A QUOTE

X
Training Workshops