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Catechol-O-methyltransferase – COMT

Gene Summary
Gene: Catechol-O-methyltransferase
Gene Symbol: COMT
Related Analyte(s): Alpha-Amylase, Cortisol
Common SNPs
Assay Methodology
Methodology: Genomic DNA, purified using silica based membrane columns is analyzed by TaqMan® SNP Genotyping Assays run on the 7900HT real time PCR system
Yield: 2-5 ug genomic DNA

Collect Saliva Samples


Better results begin with better saliva collection. This collection protocol features general considerations to maximize salivary DNA analysis. Use this collection protocol to plan your collection methodology and sampling schemes.


Test Saliva Samples

@ Salimetrics
Salimetrics SalivaLab - Easy & Accurate
Order Code (lab): 5811 (SNP Genotyping)
Transport Requirements: Ship on Dry Ice
@ Your Own Lab
Salimetrics Assay Kits - Better Results

The validated method used by Salimetrics is proprietary and not available in assay kit form at this time.

References & COMT Related Research

  1. Grossman, MH. et al. (1992). Chromosomal mapping of the human catechol-O-methyltransferase gene to 22q11.1—-q11.2. Genomics. 12(4), 822-825
  2. Bruder, Ge. et al. (2005). Catechol-O-methyltransferase (COMT) genotypes and working memory: associations with differing cognitive operations. Biological Psychiatry. 58(11), 901-907.
  3. Robinson, S. et al. (2009). Executive functions in children with autism spectrum disorders. Brain and Cognition. 71(3), 362-368.
  4. Lachman, HM. et al. (1996). Association of codon 108/158 catechol-O-methyltransferase gene polymorphism with the psychiatric manifestations of velo-cardio-facial syndrome. American Journal of Medical Genetics. 67(5), 468-472.
  5. Chen, J. et al. (2004). Functional Analysis of Genetic Variation in Catechol-O-Methyltransferase (COMT): Effects on mRNA, Protein, and Enzyme Activity in Postmortem Human Brain. American Journal of Medical Genetics. 75(5), 807-821.
  6. Stein, DJ. et al. (2006). Warriors versus worriers: the role of COMT gene variants. CNS Spectrums. 11(10), 745-748.
  7. Stein, M. et al. (2005). COMT Polymorphisms and Anxiety-Related Personality Traits. Neuropsychopharmacology. 30(2005), 2092-2102.
  8. Kennedy, Q. et al. (2011). The Roles of COMT val158met Status and Aviation Expertise in Flight Simulator Performance and Cognitive Ability. Behavior Genetics. 41(5), 700-708.
  9. Bhakta, SG. et al. (2012). The COMT Met158 allele and violence in schizophrenia: a meta-analysis. Schizophrenia Research. 140(1-3), 192-197.
  10. Soeiro-de-Souza, MG. et al. (2012). COMT polymorphisms as predictors of cognitive dysfunction during manic and mixed episodes in bipolar I disorder. Bipolar Disorders. 14(5), 554-564.
Contact: Salimetrics (USA)
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