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Salivary Cytokine Panel

Technical Summary

Profile Summary
Optimum Collection Volume: 100 μL
Total Number of Samples Required: 1
Assay Summary
Assay Range:
  TNF-alpha: 0.0314-380 pg/mL
  IL-1 beta: 0.0195-589 pg/mL
  IL-6: 0.0491-736 pg/mL
  IL-8: 0.0201-574 pg/mL

How to Collect Saliva for Cytokines


Better results begin with better saliva collection. This collection protocol features general considerations to maximize salivary Cytokine analysis. Use this saliva collection protocol to plan your collection methodology and sampling schemes.


References & Salivary Cytokine Research

  1. Bishop, N.C. & Gleeson, M. (2009). Acute and chronic effects of exercise on markers of mucosal immunity. AFront Biosci, 14, 4444-56.
  2. Brandtzaeg, P. (2007). Do salivary antibodies reliably reflect both mucosal and systemic immunity? . Ann N Y Acad Sci, 1098, 288-311.
  3. Brennan, M.T. & Fox, P.C. (2000). Cytokine mRNA expression in the labial salivary glands of healthy volunteers. Oral Dis, 6(4), 222-26.
  4. Chiapelli, F., Iribarren, F.J., & Prolo, P. (2006). Salivary biomarkers in psychobiological medicine. . Bioinformation, 1(8), 331-4.
  5. Minetto, M.A., Gazzoni, M., Fanfranco, F., Baldi, M., Saba, L., Pedrola, R., Komi, P.V., & Rainoldi, A. (2007). Influence of the sample collection method on salivary interleukin-6 levels in resting and post-exercise conditions. Eur J Appl Physiol, 101(2), 249-56.
  6. Ng, P.Y., Donley, M., Hausmann, E., Hutson, A.D., Rossomando, E.F., & Scannapieco, F.A. (2007). Candidate salivary biomarkers associated with alveloar bone loss: Cross-sectional and in vitro studies. FEMS Immuno Med Microbiol, 49(2), 252-60.
  7. Ruhl, S., Hamberger, S., Betz, R., Sukkar, T., Schmalz, G., Seymour, R.A., Hiller, K.A., & Thomason, J.M. (2004). Salivary proteins and cytokines in drug-induced gingival overgrowth. J Dent Res, 83(4), 322-6.
  8. Sjögren, E., Leanderson, P., Kristenson, M., & Ernerudh, J. (2006). Interleukin-6 levels in relation to psychosocial factors: Studies on serum, saliva, and in vitro production by blood mononuclear cells. . Brain Behav Immun, 20(3), 270-78.
  9. Wozniak, K.L. Arribas, A., Leigh, J.E., & Fidel, P.L., Jr. (2002). Inhibitory effects of whole and parotid saliva on immunomodulators. Oral Microbiol Immunol, 17(2), 100-07.
Contact: Salimetrics (USA)
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