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Salivary Interleukin-6

Technical Summary

Analyte Summary
Analyte: Interleukin-6
Aliases: IL-6
Serum-Saliva Correlation: NA
Optimum Collection Volume: 135 μL*
*Add 300 µl to the total volume of all tests for liquid handling
Assay Summary
Methodology: ELISA
Sensitivity: 0.07 pg/mL
Assay Range: 0 – 100 pg/mL
Assay Type: Quantitative
*In normal, healthy individuals IL-6 ranges commonly fall below the level of detection

Collect Saliva Samples


Better results begin with better saliva collection. This collection protocol features general considerations to maximize salivary IL-6 analysis. Use this analyte specific collection protocol to plan your collection methodology and sampling schemes.


Test Saliva Samples

@ Salimetrics
Salimetrics SalivaLab - Easy & Accurate
Order Code (lab): 5210
Transport Requirements: Ship on Dry Ice
Related Panels and Profiles: Salivary Cytokine Panel
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Salimetrics Assay Kits - Better Results

Add DNA Analysis to My Study

Considerations for adding Salivary DNA to analyte Studies:

You can combine salivary analytes with easy, accurate, and affordable genomic testing using Salimetrics SalivaLab and the same sample that you are already collecting – no specialized saliva collection devices or additional samples are required.

Don’t know what SNPs are right for you? The SalivaLab’s DNA team specializes in genetic testing services, we recommend you Request a DNA Consult (gratis) to learn more about common considerations such as # of samples, participant ethnicity, and IRB Approval.

All DNA Services

DNA Extraction and Normalization
Single Nucleotide Polymorphism (SNP) Genotyping
VNTR & STR Analysis

References & Salivary IL-6 Research

      1. McCarty, M.F. (1999). Interleukin-6 as a central mediator of cardiovascular risk associated with chronic inflammation, smoking, diabetes, and visceral obesity: Down-regulation with essential fatty acids, ethanol and pentoxifylline.  Med Hypotheses, 52(5), 465-77.
      2. Castell, J.V., Gomez-Lechon, M.J., David, M., et al. (1990).  Acute-phase response of human hepatocytes: Regulation of acute-phase protein synthesis by interleukin-6.  Hepatology, 12(5), 1179-86.
      3. Chai, Z., Gatti, S., Toniatti, C., et al. (1996). Interleukin (IL)-6 gene expression in the central nervous system is necessary for fever response to lipopolysaccharide or IL-1β: A study on IL-6-deficient mice.  J Exp Med, 183(1), 311-16.
      4. Tilg, H., Trehu, E., Atkins, M.B. (1994).  Interleukin-6 (IL-6) as an anti-inflammatory cytokine: Induction of circulating IL-1 receptor antagonist and soluble tumor necrosis factor receptor p55.  Blood, 83(1), 113-18.
      5. Sun, D., Emmert-Buck, M.R., Fox, P.C. (1998).  Differential cytokine mRNA expression in human labial minor salivary glands in primary Sjögren’s syndrome.  Autoimmunity, 28(3), 125-37.
      6. Tishler, M., Yaron, I., Shirazi, I., et al. (1999).  Increased salivary interleukin-6 levels in patients with primary Sjögren’s syndrome.  Rheumatol Int, 18(4), 125-27.
      7. Costa, P.P., Trevisan, G.L., Macedo, G.O., et al.  (2010).  Salivary interleukin-6, matrix metalloproteinase-8, and osteoprotegerin in patients with periodontitis and diabetes.  J Periodontology, 81(3), 384-91.
      8. El-Sheikh, M., Buckhalt, J.A., Granger, D.A., et al. (2007).  The association between children’s sleep disruption and salivary interleukin-6.  J Sleep Res, 16(2), 188-97.
      9. Sjögren, E., Leanderson, P., Kristenson, M., Ernerudh, J. (2006).  Interleukin-6 levels in relation to psychosocial factors: Studies on serum, saliva, and in vitro production by blood mononuclear cells.  Brain Behav Immun, 20(3), 270-78.
      10. Groer, M., Murphy, r., bunnell, W., et al. (2010).  Salivary measures of stress and immunity in police officers engaged in simulated critical incident scenarios.  J Occup Environ Med, 52(6), 595-602.
      1. Tanda, N., Ohyama, H., Yamakawa, M., et al. (1998). IL-1β and IL-6 in mouse parotid acinar cells: Characterization of synthesis, storage, and release.  Am J Physiol, 274(1 Pt 1), G147-56.

Contact: Salimetrics (USA)
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Salimetrics’ COVID-19 Status – 6 April 2020 – No change to Prior Update:

Salimetrics’ Sales and Customer Service, as well as all other non-laboratory personnel, have successfully transitioned to working remote and are fully able to provide support to our customers.

Our Salimetrics Pennsylvania Manufacturing Center remains open for customer orders and shipments. All Salimetrics’ laboratory personnel are following PPE guidelines per CDC Biosafety Level 2 (BSL-2).

The Salimetrics’ SalivaLab, located in California, is open to receive samples. In accordance with State of California Executive Order N-33-20 effective March 19, 2020, our Carlsbad, California facility, including R&D and SalivaLab personnel, will remain open working on research critical to the COVID-19 response; onsite SalivaLab personnel will be able to receive samples, and in some cases, test and send data.  All Salimetrics’ laboratory personnel are following PPE guidelines per CDC Biosafety Level 2 (BSL-2).



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