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Salivary Interleukin-6

Technical Summary

Analyte Summary
Analyte: Interleukin-6
Aliases: IL-6
Serum-Saliva Correlation: NA
Optimum Collection Volume: 135 μL*
*Add 300 µl to the total volume of all tests for liquid handling
Assay Summary
Methodology: ELISA
Sensitivity: 0.07 pg/mL
Assay Range: 0 – 100 pg/mL
Assay Type: Quantitative
Methodology: ECL
Sensitivity: 0.06 pg/mL
Assay Range: 0.06 – 3068 pg/mL
Assay Type: Quantitative
*In normal, healthy individuals IL-6 ranges commonly fall below the level of detection

Collect Saliva Samples


Better results begin with better saliva collection. This collection protocol features general considerations to maximize salivary IL-6 analysis. Use this analyte specific collection protocol to plan your collection methodology and sampling schemes.

Test Saliva Samples

@ Salimetrics
Salimetrics SalivaLab - Easy & Accurate
Order Code (lab): 5210
Transport Requirements: Ship on Dry Ice
Related Panels and Profiles: Salivary Cytokine Panel
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Add DNA Analysis to My Study

Considerations for adding Salivary DNA to analyte Studies:

You can combine salivary analytes with easy, accurate, and affordable genomic testing using Salimetrics SalivaLab and the same sample that you are already collecting – no specialized saliva collection devices or additional samples are required.

Don’t know what SNPs are right for you? The SalivaLab’s DNA team specializes in genetic testing services, we recommend you Request a DNA Consult (gratis) to learn more about common considerations such as # of samples, participant ethnicity, and IRB Approval.

All DNA Services

DNA Extraction and Normalization
Single Nucleotide Polymorphism (SNP) Genotyping
VNTR & STR Analysis

References & Salivary IL-6 Research

      1. McCarty, M.F. (1999). Interleukin-6 as a central mediator of cardiovascular risk associated with chronic inflammation, smoking, diabetes, and visceral obesity: Down-regulation with essential fatty acids, ethanol and pentoxifylline.  Med Hypotheses, 52(5), 465-77.
      2. Castell, J.V., Gomez-Lechon, M.J., David, M., et al. (1990).  Acute-phase response of human hepatocytes: Regulation of acute-phase protein synthesis by interleukin-6.  Hepatology, 12(5), 1179-86.
      3. Chai, Z., Gatti, S., Toniatti, C., et al. (1996). Interleukin (IL)-6 gene expression in the central nervous system is necessary for fever response to lipopolysaccharide or IL-1β: A study on IL-6-deficient mice.  J Exp Med, 183(1), 311-16.
      4. Tilg, H., Trehu, E., Atkins, M.B. (1994).  Interleukin-6 (IL-6) as an anti-inflammatory cytokine: Induction of circulating IL-1 receptor antagonist and soluble tumor necrosis factor receptor p55.  Blood, 83(1), 113-18.
      5. Sun, D., Emmert-Buck, M.R., Fox, P.C. (1998).  Differential cytokine mRNA expression in human labial minor salivary glands in primary Sjögren’s syndrome.  Autoimmunity, 28(3), 125-37.
      6. Tishler, M., Yaron, I., Shirazi, I., et al. (1999).  Increased salivary interleukin-6 levels in patients with primary Sjögren’s syndrome.  Rheumatol Int, 18(4), 125-27.
      7. Costa, P.P., Trevisan, G.L., Macedo, G.O., et al.  (2010).  Salivary interleukin-6, matrix metalloproteinase-8, and osteoprotegerin in patients with periodontitis and diabetes.  J Periodontology, 81(3), 384-91.
      8. El-Sheikh, M., Buckhalt, J.A., Granger, D.A., et al. (2007).  The association between children’s sleep disruption and salivary interleukin-6.  J Sleep Res, 16(2), 188-97.
      9. Sjögren, E., Leanderson, P., Kristenson, M., Ernerudh, J. (2006).  Interleukin-6 levels in relation to psychosocial factors: Studies on serum, saliva, and in vitro production by blood mononuclear cells.  Brain Behav Immun, 20(3), 270-78.
      10. Groer, M., Murphy, r., bunnell, W., et al. (2010).  Salivary measures of stress and immunity in police officers engaged in simulated critical incident scenarios.  J Occup Environ Med, 52(6), 595-602.
      1. Tanda, N., Ohyama, H., Yamakawa, M., et al. (1998). IL-1β and IL-6 in mouse parotid acinar cells: Characterization of synthesis, storage, and release.  Am J Physiol, 274(1 Pt 1), G147-56.

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