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Circadian Locomotor Output Cycles Kaput – CLOCK

Gene Summary
Gene: Circadian Locomotor Output Cycles Kaput
Gene Symbol: CLOCK
Related Analyte(s): Melatonin, Insulin, Cortisol
Common SNPs
rs1801260 , rs11932595
Assay Methodology
Genomic DNA, purified using silica based membrane columns is analyzed by TaqMan® SNP Genotyping Assays run on the 7900HT real time PCR system
Yield: 2-5 ug genomic DNA

Collect Saliva Samples

DNA SALIVA COLLECTION CONSIDERATIONS

Better results begin with better saliva collection. This collection protocol features general considerations to maximize salivary DNA analysis. Use this collection protocol to plan your collection methodology and sampling schemes.

APPROVED SALIVARY DNA COLLECTION METHODS

Test Saliva Samples

@ Salimetrics
Salimetrics SalivaLab - Easy & Accurate
Order Code (lab): 5811 (SNP Genotyping)
Transport Requirements: Ship on Dry Ice
@ Your Own Lab
Salimetrics Assay Kits - Better Results

The validated method used by Salimetrics is proprietary and not available in assay kit form at this time.

References & Salivary CLOCK Related Research

  1. Edgar, R. et al. (2012). Peroxiredoxins are conserved markers of circadian rhythms. Nature. 485(7399), 459-464.
  2. NCBI: CLOCK clock circadian regulator [ Homo sapiens (human) ]
  3. Hardin, P. et al. (2000). From biological clock to biological rhythms. Genome Biology. 1(4), 1023.1-1023.5.
  4. Kissling, C. et al. (2008). A polymorphism at the 3′-untranslated region of the CLOCK gene is associated with adult attention-deficit hyperactivity disorder. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 147(3), 333-338.
  5. Xu, X. et al. (2010). Association study between a polymorphism at the 3′-untranslated region of CLOCK gene and attention deficit hyperactivity disorder. Behavioral and brain functions: BBF. 6,48.
  6. Garaulet, M. et al. (2011). Ghrelin, Sleep Reduction and Evening Preference: Relationships to CLOCK 3111 T/C SNP and Weight Loss. PLoS ONE, 6(2), e17435.
  7. Vanderlind, W. M. et al. (2014). Sleep and sadness: exploring the relation among sleep, cognitive control, and depressive symptoms in young adults. Sleep Medicine, 15(1), 144–149.