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Circadian Locomotor Output Cycles Kaput – CLOCK

Biomarkers

TECHNICAL SUMMARY

Gene Summary
Gene: Circadian Locomotor Output Cycles Kaput
Gene Symbol: CLOCK
Related Analyte(s): Melatonin, Insulin, Cortisol
Common SNPs
rs1801260 , rs11932595
Assay Methodology
Genomic DNA, purified using silica based membrane columns is analyzed by TaqMan® SNP Genotyping Assays run on the 7900HT real time PCR system
Yield: 2-5 ug genomic DNA
Biomarkers

How to collect Circadian Locomotor Output Cycles Kaput – CLOCK

APPROVED SALIVARY DNA COLLECTION METHODS

References & Salivary CLOCK Related Research

  1. Edgar, R. et al. (2012). Peroxiredoxins are conserved markers of circadian rhythms. Nature. 485(7399), 459-464.
  2. NCBI: CLOCK clock circadian regulator [ Homo sapiens (human) ]
  3. Hardin, P. et al. (2000). From biological clock to biological rhythms. Genome Biology. 1(4), 1023.1-1023.5.
  4. Kissling, C. et al. (2008). A polymorphism at the 3′-untranslated region of the CLOCK gene is associated with adult attention-deficit hyperactivity disorder. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 147(3), 333-338.
  5. Xu, X. et al. (2010). Association study between a polymorphism at the 3′-untranslated region of CLOCK gene and attention deficit hyperactivity disorder. Behavioral and brain functions: BBF. 6,48.
  6. Garaulet, M. et al. (2011). Ghrelin, Sleep Reduction and Evening Preference: Relationships to CLOCK 3111 T/C SNP and Weight Loss. PLoS ONE, 6(2), e17435.
  7. Vanderlind, W. M. et al. (2014). Sleep and sadness: exploring the relation among sleep, cognitive control, and depressive symptoms in young adults. Sleep Medicine, 15(1), 144–149.

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Contact: Salimetrics (USA)
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