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Salivary Osteocalcin

Technical Summary

Analyte Summary
Analyte: Osteocalcin
Aliases: OCN, OC, Bone Gamma-Carboxyglutamic Acid-Containing Protein (BGLAP),
Serum-Saliva Correlation: NA
Optimum Collection Volume: 150 μL
Assay Summary
Methodology: ECL
Sensitivity: 9.77 pg/mL
Assay Range: 9.77–10,000 pg/mL
Assay Type: Quantitative

How to Collect Saliva


Better results begin with better saliva collection. This collection protocol features general considerations to maximize salivary osteocalcin analysis. Use this analyte-specific collection protocol to plan your collection methodology and sampling schemes.


Test Samples at Salimetrics

@ Salimetrics
Salimetrics SalivaLab - Easy & Accurate
Order Code (lab): 5212
Transport Requirements: Ship on Dry Ice
@ Your Own Lab
Salimetrics Assay Kits - Better Results

The validated method used by Salimetrics is proprietary and not available in assay kit form at this time.

Add DNA Analysis to My Study

Considerations for adding Salivary DNA to analyte Studies:

You can combine salivary analytes with easy, accurate, and affordable genomic testing using Salimetrics SalivaLab and the same sample that you are already collecting – no specialized saliva collection devices or additional samples are required.

Don’t know what SNPs are right for you? The SalivaLab’s DNA team specializes in genetic testing services, we recommend you Request a DNA Consult (gratis) to learn more about common considerations such as # of samples, participant ethnicity, and IRB Approval.

All DNA Services

DNA Extraction and Normalization
Single Nucleotide Polymorphism (SNP) Genotyping
VNTR & STR Analysis

References & Salivary Osteocalcin Research

    1. Berger, Julian Meyer, et al. (2019) Mediation of the Acute Stress Response by the Skeleton. Cell Metabolism. US National Library of Medicine, S 1550- 4131(19)30441-3. PMID: 31523009
    2. Mera, Paula, et al. (2016) Osteocalcin Signaling in Myofibers is Necessary and Sufficient for Optimum Adaptation to Exercise. Cell Metab, US national Library of Medicine, 23(6): 1078-1092.
    3. Moser, Sarah C., and Bram C. J. Van Der Eerden. (2019) Osteocalcin- A Versatile Bone Derived Hormone. Frontiers in Endocrinology, 9: 794.
    4. Obri, Arnaud, et al. ( 2018) Osteocalcin in the Brain: from Embryonic Development to Age-Related Decline in Cognition. Nature Reviews Endocrinology, 14, 174-182.
    5. Karsenty, Gerard, and Franck Oury. (2014) Regulation of male fertility by the bone-derived hormone osteocalcin. Molecular and Cellular Endocrinology, US National Library of Medicine, 382 (1).
    6. Bullon, Pedro, et al. ( 2005)Serum, Saliva, and Gingivial Crevicular Fluid Osteocalcin: Their Relation to Periodontal Status and Bone Mineral Density in Postmenopausal Women . Journal of Periodontology, 76(4) 513-519.
    7. Gurlek, Onder, et al (2009) Effects of Smoking on Salivary C-Telopeptide Pyridinoline Cross- Links of Type I Collagen and Osteocalcin Levels. Archives of Oral Biology, 54(12) 1099-1104.
    8. Pellegrini, Gretel G, et al (2008) Correlation Between Salivary and Serum Markers of Bone Turnover in Osteopenic Rats. Journal of Periodontology, 79(1) 158-165.
    9. Kinney, J S et al (2007) Oral Fluid-Based Biomarkers of Alveolar Bone Loss in Periodontitis . Annals of the New York Academy of Sciences, 1098(1): 230-251.
    10. Miller, Craig S, et al. (2010) Current developments in Salivary Diagnostics. Biomarkers in Medicine, 4(1).

    1. Lee, Na Kyung, et al. (2007) Endocrine Regulation of Energy Metabolism by the Skeleton. Cell, US National Library of Medicine, 130(3): 456-469.
    2. Karsenty, Gerard, and Eric N. Olson. (2016) Bone and muscle endocrine functions: Unexpected paradigms of inter-organ communication. Cell, US national Library of Medicine, 164(6): 1248-1256.
    3. Sloat, Sarah. (2019) Scientists Discover Stress Comes From an Unlikely Source in the Body. Inverse.
      Oury, Franch, et al. (2011) Endocrine Regulation of Male Fertility by the Skeleton. Cell, Science Direct, 144(5) 796-809.
    4. Camerino, et al. (2018) Evaluation of Short and Long Term Cold Stress Challenge of Nerve Grow Factor, Brain-Derived Neurotrophic Factor, Osteocalcin and Oxytocin mRNA Expression in BAT, Brain, Bone and Reproductive Tissue of Male Mice Using Real-Time PCR and Linear Correlation Analysis. Frontiers in physiology, US National Library of Medicine, 8:1101.
    5. Patterson-Buckendahl. (2011) Osteocalcin is a stress-responsive neuropeptide. Endocrine regulations, US National Library of Medicine, 45(2):99-110.

Contact: Salimetrics (USA)
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Salimetrics’ COVID-19 Status – 6 April 2020 – No change to Prior Update:

Salimetrics’ Sales and Customer Service, as well as all other non-laboratory personnel, have successfully transitioned to working remote and are fully able to provide support to our customers.

Our Salimetrics Pennsylvania Manufacturing Center remains open for customer orders and shipments. All Salimetrics’ laboratory personnel are following PPE guidelines per CDC Biosafety Level 2 (BSL-2).

The Salimetrics’ SalivaLab, located in California, is open to receive samples. In accordance with State of California Executive Order N-33-20 effective March 19, 2020, our Carlsbad, California facility, including R&D and SalivaLab personnel, will remain open working on research critical to the COVID-19 response; onsite SalivaLab personnel will be able to receive samples, and in some cases, test and send data.  All Salimetrics’ laboratory personnel are following PPE guidelines per CDC Biosafety Level 2 (BSL-2).



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