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Mu-Opioid Receptor – OPRM1



Gene Summary
Gene: Opioid Receptor, mu 1
Gene Symbol: OPRM1
Related Analyte(s): Cortisol
Common SNPs
Assay Methodology
Genomic DNA, purified using silica based membrane columns is analyzed by TaqMan® SNP Genotyping Assays run on the 7900HT real time PCR system
Yield: 2-5 ug genomic DNA

How to collect Mu-Opioid Receptor – OPRM1


References & OPRM1 Related Research

  1. Haerian BS, Haerian MS. (2013). OPRM1 rs1799971 polymorphism and opioid dependence: evidence from a meta-analysis. Pharmacogenomics. PMID: 23651028
  2. Bond C, et al (1998). Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: possible implications for opiate addiction. Proc Natl Acad Sci U S A. PMID: 9689128
  3. van den Wildenberg E, et al. (2007). A functional polymorphism of the mu-opioid receptor gene (OPRM1) influences cue-induced craving for alcohol in male heavy drinkers. Alcohol Clin Exp Res. PMID: 17207095
  4. Ren ZY, et al. (2015). The impact of genetic variation on sensitivity to opioid analgesics in patients with postoperative pain: a systematic review and meta-analysis. Pain Physician. PMID: 25794200
  5. Bart G, et al. (2005). Increased attributable risk related to a functional mu-opioid receptor gene polymorphism in association with alcohol dependence in central Sweden. Neuropsychopharmacology. PMID: 15525999
  6. Way BM, et al. (2009). Variation in the mu-opioid receptor gene (OPRM1) is associated with dispositional and neural sensitivity to social rejection. Proc Natl Acad Sci U S A. PMID: 19706472
  7. Slavich GM, et al. (2014). Endogenous opioid system influences depressive reactions to socially painful targeted rejection life events. Psychoneuroendocrinology. PMID: 25086307
  8. Carver CS, et al. (2015). Mu opioid receptor polymorphism, early social adversity, and social traits. Soc Neurosci. PMID: 26527429
  9. Bergen AW, et al. (1997). Mu opioid receptor gene variants: lack of association with alcohol dependence. Mol Psychiatry. PMID: 9399694

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