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Mu-Opioid Receptor – OPRM1

Gene Summary
Gene: Opioid Receptor, mu 1
Gene Symbol: OPRM1
Related Analyte(s): Cortisol
Common SNPs
rs1799971
Assay Methodology
Genomic DNA, purified using silica based membrane columns is analyzed by TaqMan® SNP Genotyping Assays run on the 7900HT real time PCR system
Yield: 2-5 ug genomic DNA

Collect Saliva Samples

DNA SALIVA COLLECTION CONSIDERATIONS

Better results begin with better saliva collection. This collection protocol features general considerations to maximize salivary DNA analysis. Use this collection protocol to plan your collection methodology and sampling schemes.

APPROVED SALIVARY DNA COLLECTION METHODS

Test Saliva Samples

@ Salimetrics
Salimetrics SalivaLab - Easy & Accurate
Order Code (lab): 5811 (SNP Genotyping)
Transport Requirements: Ship on Dry Ice
@ Your Own Lab
Salimetrics Assay Kits - Better Results

The validated method used by Salimetrics is proprietary and not available in assay kit form at this time.

References & OPRM1 Related Research

  1. Haerian BS, Haerian MS. (2013). OPRM1 rs1799971 polymorphism and opioid dependence: evidence from a meta-analysis. Pharmacogenomics. PMID: 23651028
  2. Bond C, et al (1998). Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: possible implications for opiate addiction. Proc Natl Acad Sci U S A. PMID: 9689128
  3. van den Wildenberg E, et al. (2007). A functional polymorphism of the mu-opioid receptor gene (OPRM1) influences cue-induced craving for alcohol in male heavy drinkers. Alcohol Clin Exp Res. PMID: 17207095
  4. Ren ZY, et al. (2015). The impact of genetic variation on sensitivity to opioid analgesics in patients with postoperative pain: a systematic review and meta-analysis. Pain Physician. PMID: 25794200
  5. Bart G, et al. (2005). Increased attributable risk related to a functional mu-opioid receptor gene polymorphism in association with alcohol dependence in central Sweden. Neuropsychopharmacology. PMID: 15525999
  6. Way BM, et al. (2009). Variation in the mu-opioid receptor gene (OPRM1) is associated with dispositional and neural sensitivity to social rejection. Proc Natl Acad Sci U S A. PMID: 19706472
  7. Slavich GM, et al. (2014). Endogenous opioid system influences depressive reactions to socially painful targeted rejection life events. Psychoneuroendocrinology. PMID: 25086307
  8. Carver CS, et al. (2015). Mu opioid receptor polymorphism, early social adversity, and social traits. Soc Neurosci. PMID: 26527429
  9. Bergen AW, et al. (1997). Mu opioid receptor gene variants: lack of association with alcohol dependence. Mol Psychiatry. PMID: 9399694