(October 16, 2019)
Salimetrics brings better methods to salivary cytokine research with the addition of IFN-gamma, IL-2, IL-10, IL-12p70, and IL-13 to its testing service. Researchers can add any or all of these cytokines to the popular, core Salimetrics’ Salivary Cytokine Panel (IL-1 Beta, IL-6, IL-8 and TNF-Alpha), all tested using the same sample with a small sample volume.
Researchers can now benefit from the latest offering in industry-leading salivary research tools with expanded Salivary Cytokine Testing from the Salimetrics SalivaLab. Today, the Salimetrics’ core four cytokine panel has been broadened to include up to five additional salivary cytokines, IFN-γ, IL-2, IL-10, IL-12p70, and IL-13, putting more data in the hands of researchers ready-for-results. “We’ve taken the most accepted cytokine panel in salivary bioscience (IL-1 Beta, IL-6, IL-8 and TNF-Alpha), and validated additional cytokines that can be measured using the same sample to increase the power of your cytokine data. This is an ideal solution for research critically focused on multiple analytes to be assayed from the same sample,” says Supriya Gaitonde, Ph.D., Salimetrics Senior Applications Scientist. For related analytes, the expanded Salimetrics Salivary Cytokine Panel allows researchers to pinpoint additional correlates, interrelationships and robust trends, enabling more objective and comprehensive conclusions to be drawn without any negative impact to the study workflow or participant compliance.
The new salivary cytokines available for testing from Salimetrics gives researchers a more complete picture of the immune response in the oral cavity, which may reflect systemic biology as well. While the core panel includes cytokines that are closely related in function and more in-line with an acute inflammatory response, the added cytokines include biomarkers that are anti-inflammatory, as well as some that are critical for more chronic conditions of immune pathology or in response to ongoing infections. Investigators can choose biomarkers that create new hypotheses or validate existing ones by being more inclusive of critical biological feedback. Investigators can also trust the data they receive using the same Salimetrics’ SalivaLab expertise that they have relied on for over twenty years.
Cytokine testing from Salimetrics requires only 50 microliters of saliva regardless of the number of cytokines tested. Small sample volumes are advantageous for researchers who have a majority of participants with conditions or limitations that influence the normal flow of saliva. This can be especially beneficial in infant, children, or studies where researchers may be limited by collecting only the amount of saliva that is absolutely necessary to perform the assay. “Salimetrics has completed a rigorous validation for each cytokine, and the new menu is the result of our effort to bring researchers options that provide robust access to salivary cytokines,” says Steve Granger Ph.D., Salimetrics CSO.
Salimetrics performed a fit for purpose validation on each of the cytokines in the new offering to ensure that the most reliable data would be delivered. “The Salimetrics’ validation focuses on sample integrity, reproducibility and accuracy, so that only the most robust solutions are offered,” says Dr. Gaitonde. “We focus on the quality rather than quantity of our products and services because they represent our commitment to better methods for salivary bioscience.” An assay validation for use in saliva, performed by Salimetrics, provides researchers with a credible foundation that the data received is accurate. “It may sound counterproductive, but not all labs validate their assays and protocols for each sample type, often leading to increased risk of bias. We recommend investigators request and review a validation report from any lab utilizing any lab-developed test, not offered to researchers in a commercial kit form,” says Dr. Gaitonde.
To learn more about cytokines in saliva, the expanded salivary cytokine panel, or additional saliva tests and services from the Salimetrics SalivaLab, researchers can visit the Salimetrics Website or contact Salimetrics for more details. Dr. Granger notes, “We are happy to offer this expanded service to the family of Salivary Bioscience researchers, because we are actively committed to providing access to the best and most accurate salivary bioscience methods to researchers around the world – and we make it easy – just contact us.”
Salimetrics’ assay kits and CLIA-certified testing services are used to measure salivary analytes related to stress, behavior and development, inflammation, sleep, reproduction, health and immune function. Founded in 1998 by Douglas A. Granger, Ph.D., Salimetrics, LLC supports CROs, pharmaceuticals, academic researchers and the immunodiagnostic industry around the world with innovative immunoassay products, non-invasive saliva collection methods, and laboratory testing services.
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