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Archives: Analytes

C-Reactive Protein in Saliva

Salivary C-Reactive Protein

C-Reactive Protein (CRP) circulates in the blood plasma as a stable homopentamer and a prominent member of the acute-phase inflammatory proteins. CRP functions mainly in innate immune defense and levels increase in response to inflammation, infection, tissue damage, necrosis, malignancy and allergic reactions (1). CRP has diagnostic value as a marker of systemic inflammation in […]

Androstenedione in Saliva

Salivary Androstenedione

​Androstenedione (4-androstenedione; 4-dione; 4-androstene-3,17-dione) is a steroid hormone produced in the adrenal glands and the gonads. (1,2,3) It is synthesized from DHEA or 17OH-progesterone, and it serves principally as the immediate precursor compound that is converted into testosterone or estrone, both of which may then be further converted into estradiol. (4)  The same sequence of conversion of DHEA and androstenedione […]

Salivary Alpha Amylase

Salivary Alpha-Amylase

​​Alpha-Amylase (or α-Amylase) is a digestive enzyme that hydrolyses alpha-1,4 bonds of large polysaccharides such as starch and glycogen, yielding the smaller by-products of glucose and maltose. (1) Alpha amylase is synthesized in the acinar cells of the saliva glands and stored in secretory granules inside these cells. (2) Its release from the salivary cells […]

Aldosterone in Saliva

Salivary Aldosterone

Recent studies have shown that primary aldosteronism (PA) is the most common cause of secondary hypertension with a prevalence of approximately 5-10% among all hypertensive patients and an even higher prevalence among selected patients with advanced stages of hypertension and resistant hypertension. (1)  Screening for PA among hypertensive patients is important due ​to its association with risk […]

17OHP in Saliva

Salivary 17 Alpha-OHP

17α-hydroxyprogesterone (17-OH progesterone or 17OHP) is a steroid hormone produced in the adrenal gland and gonads. (1,2,3) It is synthesized from progesterone, and it serves primarily as a precursor compound that is converted into cortisol in the adrenal gland, or into androgenic and estrogenic steroid hormones in the gonads. (3,4) 17-OHP is routinely used for […]

Salivary Cortisol

Salivary Cortisol

Cortisol (hydrocortisone, Compound F) is the major glucocorticosteroid hormone produced in the adrenal cortex. Cortisol is actively involved in the regulation of calcium absorption, blood pressure maintenance, anti-inflammatory function, gluconeogenesis, gastric acid, pepsin secretion, and immune function. (1,2,3) Cortisol production has a circadian rhythm. (4) Levels peak in the early morning and drop to the […]

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