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Salivary SARS-CoV-2 (N) IgG
There is an urgent need to better understand COVID-19 antibody levels and duration of protective immunity for public health considerations. Coronavirus antibody testing in saliva has shown utility as a sensitive and specific serum alternative for large scale immune-surveillance studies (1). Importantly, IgG in saliva is derived from serum, so specificity and reactivity of salivary […]
Salivary IgM
Immunoglobulin M, or IgM, is present in two major forms in the circulation referred to as natural or adaptive (1). Natural IgMs are low affinity pentameric molecules that bind to invading pathogens without requiring prior exposure (2). They act to directly neutralize viruses, activate complement, trigger phagocytosis and drive antibody dependent cell cytotoxicity (3). Adaptive […]
Salivary IgG
Immunoglobulin G (IgG) is critical for host immune-defense against infectious pathogens and is the most abundant antibody found in blood. Within the IgG class, there are four subclasses (IgG1, IgG2, IgG3 and IgG4). The term total IgG collectively refers to all IgG subclasses all of which have varying unique reactivities. In most cases an immune […]
Salivary Osteocalcin
Osteocalcin (also known as OCN, OC, and Bone-Gla-Protein (BGP) or bone gamma-carboxyglutamic acid-containing protein (BGLAP)), is a bone-derived hormone protein released solely by osteoblasts during bone remodeling in vertebrates. Research interest in Osteocalcin has revealed endocrine-related properties related to several physiological pathways. Recent findings suggest that Osteocalcin may also be a key factor in the […]
Salivary DLMO Profile
Need a DLMO Test? Salimetrics all-inclusive, Home DLMO Test Kit for researchers, clinicians, or personal use is now available. Dim Light Melatonin onset as a biomarker for the analysis of circadian rhythm, for chronobiological disorders and obstructive sleep-wake phase shifts. With the increased clinical focus on sleep as it relates to many aspects of […]
Salivary Uric Acid
Salivary uric acid may be a useful biomarker for oxidative stress research and monitoring metabolic syndrome to help mitigate cardiometabolic risk. Several studies have reported that a linear relationship exists between uric acid levels in serum and saliva. Uric acid is the most prevalent antioxidant in blood and minimizes the systemic physiological stress of free-radical […]
Salivary Total Protein
Total protein is a non-specific measure of the total amount of all proteins present in a solution. It is used to examine changes in overall protein secretion in blood or saliva that are associated with disease states, or to look for differences in the ratio of specific proteins (or other analytes) to total protein that […]
Salivary TNF-Alpha
*Also available as part of the Salimetrics Cytokine Panel* Tumor necrosis factor alpha (TNF-Alpha) is a member of a family of small biologically active proteins known as cytokines. TNF-α plays a key role in the innate inflammatory response in vertebrates. When macrophages and T cells detect an invading pathogen, they produce TNF-α, triggering local […]
Salivary Testosterone
Testosterone is an anabolic steroid hormone synthesized from androstenedione in the Leydig cells of the testes of males and, in smaller quantities, in the ovaries of females. (1) Small amounts are also secreted by the adrenal glands in both sexes. In both men and women a large portion of total testosterone production occurs in peripheral tissues by conversion of circulating DHEA-S, DHEA, and androstenedione. […]
Salivary SIgA
Secretory Immunoglobulin A (SIgA) is a subclass of Immunoglobulin A (IgA), an antibody that plays a critical role in mucosal immunity. SIgA is the main immunoglobulin found in mucous secretions from tear glands, salivary glands, mammary glands, the respiratory system, the genito-urinary tract, and the gastrointestinal tract. (1) SIgA is not synthesized by mucosal epithelial cells in […]
Salivary Progesterone
Progesterone (4-pregenene-3,20-dione) is a steroid hormone of primary importance in ovulation, fertility, pregnancy, and menopause. Synthesis of progesterone takes place in the placenta, adrenal glands, and gonads. (1-4) In normal, non-pregnant women during the mid-luteal phase of the menstrual cycle, progesterone exhibits a prominent circadian rhythm with additional ultradian components. Peak production occurs in the […]
Salivary Melatonin
Analysis of melatonin in saliva effectively enables researchers to design non-invasive studies that assess circadian timing and evaluate the degree of circadian phase abnormalities in association with major diseases, conditions, administration of pharmaceutical compounds, seasonal affective disorder, jet-lag and night shift work, etc., due to a strong correlation with serum melatonin concentrations. It also pertains […]
Salivary Interleukin-6
Interleukin-6 (IL-6) is one of a family of biologically active small protein molecules known as cytokines. It is released by a variety of tissues, including activated leukocytes, adipocytes, and endothelial cells, and it is involved in many processes in the body. IL-6 plays an important role in stimulating the immune response to infection or trauma […]
Salivary Interleukin-1 Beta
*Also available as part of the Salimetrics Cytokine Panel* Interleukin-1β (IL-1 beta) is one of a family of biologically active small protein molecules known as cytokines. Cytokines are produced by a number of different cell types, including macrophages, monocytes, fibroblasts, and dendritic cells. (1,2,3) IL-1β is an example of a pro-inflammatory cytokine, since it is involved […]