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Salivary Bioscience News

Co-Exposed Children Displayed a Lower Cortisol response than Non-exposed Children

Prenatal Tobacco & Cannabis Exposure: Associations With Cortisol Reactivity in Early School Age Children

Eiden, et al. 2020 International Journal of Behavioral Medicine

Background.  The study examined the association between prenatal tobacco or co-exposure to tobacco and cannabis and children’s cortisol reactivity at kindergarten age, and the role of child sex, maternal negative mood (depression/perceived stress), and parenting behavior during play interactions as moderators of this association.

Methods.  The sample was 238 mother-child dyads (67 tobacco users, 83 co-users of tobacco and cannabis, and 88 non-users).  Data used were obtained from pregnancy assessments, and six postnatal assessments at 2, 9, 16, 24, 36 months, and kindergarten age. Infant cortisol was measured in response to two laboratory stress paradigms.

Results. Co-exposed children had a significantly greater decrease from pre-stressor to post-stressor and overall lower cortisol response compared to non-exposed children.  This association was moderated by maternal harshness during play interactions across early childhood. Co-exposed children had flatter cortisol responses regardless of the mother’s level of harshness or stress/depression.  However, non-exposed children who experienced low harshness had the normative cortisol peak 20 minutes post-stressor while non-exposed children with high maternal harshness had a flatter cortisol pattern.  Similarly, non-exposed children with more depressed/stressed mothers had higher pre-stressor cortisol levels while those who experienced low maternal depression/stress had lower pre-stressor cortisol but peaked post-stress.

Conclusions. Results suggest that prenatal polysubstance exposure is associated with greater risk for lower cortisol response in children, and highlight the role of parenting behavior for non-exposed but not the co-exposed children.

View Abstract

Keywords: Salivary cortisol, tobacco, cannabis, prenatal, maternal depression

*Note: Salimetrics provides this information for research use only (RUO). Information is not provided to promote off-label use of medical devices. Please consult the full-text article.

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