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Statistical Approaches to Reduce Bias in Left-censored Salivary Data
Censored Data Considerations and Analytical Approaches for Salivary Bioscience Data Ahmadi, H. et al., (2021) Psychoneuroendorcinology ABSTRACT: Left censoring in salivary bioscience data occurs when salivary analyte determinations fall below the lower limit of an assay’s measurement range. Conventional statistical approaches for addressing censored values (i.e., recoding as missing, substituting or extrapolating values) may introduce […]
Salivary Bioscience Research for Nordic Region Investigators
Have you met XboXLab? XboXLab is one of Salimetrics trusted international distributors covering the Nordic region (Norway, Finland, Sweden, Denmark). Their team consists of knowledgeable and experienced employees ready to assist researchers and suppliers. XboXLab and Salimetrics both align in their fundamental goal of fulfilling salivary bioscience research needs by providing customers with high-quality SalivaBio […]
Blunted Morning Salivary Cortisol Associated with Cardiovascular Risk
Blunted circadian cortisol in children is associated with poor cardiovascular health and may reflect circadian misalignment Dai, W. et al., ( 2021) Psychoneuroendocrinology ABSTRACT: Objectives: Circadian cues in children (sunlight, exercise, diet patterns) may be associated with health outcomes. The primary objective was to assess associations of daily cortisol fluctuations (morning, night) with cardiovascular health […]
Salivary cortisol correlates with DNA methylation in preterm infants
DNA methylation in former extremely low birth weight newborns: association with cardiovascular and endocrine function Padbury, J. et al., (2021) Pediatric Research ABSTRACT: Background: There is increased risk of cardiovascular, metabolic, and hypertensive disorders in later life in the preterm population. We studied school-age children who had been born extremely premature who had undergone endocrine, […]
Salivary SARS-CoV-2 IgG Assay: A practical alternative for screening and monitoring vaccine antibody response and seroprevalence.
Comparative performance of multiplex salivary and commercially available serologic assays to detect SARS-CoV-2 IgG and neutralization titers Heaney et al., ( 2021) medRxiv ABSTRACT: Oral fluid (hereafter saliva) offers a non-invasive sampling method for the detection of SARS-CoV-2 antibodies. However, data comparing performance of salivary tests against commercially-available serologic and neutralizing antibody (nAb) assays are […]
The role of Salivary Cortisol and Progesterone in female friendships
The endocrinology of female friendships: Cortisol and progesterone attunement after separation Rankin et al., (2021) Biological Psychology ABSTRACT: Friendships constitute important relationships, and often function to reduce stress, but have been under-studied. In mother-child dyads, infants coordinate their stress response with their caregivers without experiencing the stressor themselves. The current study used a modified version […]
Increased altruism in children during distress may benefit from “tend-and-befriend” behavior
Children’s Altruism Following Acute Stress: The Role of Autonomic Nervous System Activity and Social Support V Alen et al., (2021) Developmental Science ABSTRACT: Altruistic behavior after stress exposure may have important health and psychological benefits, in addition to broader societal consequences. However, so far experimental research on altruism following acute stress has been limited to […]
Neuroscience Meets Salivary Bioscience: Interaction between sex, stress reactivity, and cingulum GFA
Sex-related differences in stress reactivity and cingulum white matter Wheelock, et al., ( 2021) Neuroscience ABSTRACT: The prefrontal cortex and limbic system are important components of the neural circuit that underlies stress and anxiety. These brain regions are connected by white matter tracts that support neural communication including the cingulum, uncinate fasciculus, and the fornix/stria-terminalis. […]
Zoom Webinar: Christopher D. Heaney, PhD., Johns Hopkins University – Using a Multiplex Salivary Antibody Assay to Measure SARS-CoV-2 Infection and Vaccination at Population-Scale
June 3rd, 2021 10:00am PST Zoom Webinar CHRISTOPHER D. HEANEY, PHD Bloomberg School of Public Health Johns Hopkins University ABSTRACT Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of an ongoing pandemic that has infected millions of people across the globe. Informed implementation of government public health policies depends on accurate data on [...]
Salivary Bioscience Studies That Have Impact: Getting Back to Our ABCDs
(May 12, 2021) Since being funded in 2015, the Adolescent Brain and Cognitive Development (ABCD) Study has enrolled more than 10,000 children with the objective to study numerous facets of cognitive, social, emotional, and physical development over 10 years. This multi-site, nationwide epidemiologic study is the largest of its type and focus to date. Salimetrics’ [...]
Robust relationship between DHEA and emerging symptoms of pathological worry during adolescence
Increased dehydroepiandrosterone (DHEA) is associated with anxiety in adolescent girls Mulligan EM, et al., (2020) Psychneuroendocrinology ABSTRACT: The pubertal period is a time of rapid increase in the incidence of anxiety disorders, and thus, pubertal hormones may play a role in the precipitation of anxious psychopathology. DHEA, a steroid hormone that surges in adolescence, has […]
Impacting Associations Between Salivary Cortisol and Alpha-Amylase and Child Depressive Symptoms.
Child depressive symptoms: Associations with salivary cortisol and alpha amylase in two distinct challenges Khoury JE, et al., ( 2020) Biological psychology ABSTRACT: Child depression has been inconsistency linked to cortisol and salivary alpha-amylase (sAA) reactivity. This study assessed three factors that contribute to inconsistencies: 1) the differential effectiveness of laboratory challenges to elicit cortisol […]
Salimetrics Online Workshops – Translating the Best Guide, “Foundations of Interdisciplinary Saliva Research & Applications”, into Easy Steps for Research Applications
(March 31, 2021) Based on the book “Salivary Bioscience - Foundations of Interdisciplinary Saliva Research and Applications”, Salimetrics has expanded its workshop series to provide practical steps for research and diagnostics using saliva as the specimen. For over 20 years, Salimetrics has supported the Salivary Bioscience field by providing best methods for sample collection and [...]
New Recommendations for Repeatability in Salivary Bioscience Data
The case for the repeatability intra-class correlation as a metric of precision for salivary bioscience data: Justification, assessment, application, and implications Riis, JL. et al., (2021) Psychoneuroendocrinology Summary Highlight: This study highlights how advances in salivary assay precision, combined with a qualified laboratory reduces the necessity to test samples in duplicate. As best practice standards [...]