(July 09, 2015)
Salimetrics introduces an innovative Salivary Uric Acid Enzymatic Assay, facilitating easy monitoring of Uric Acid levels with saliva samples (no needles, no phlebotomist, fast, easy and less expensive). This uric acid assay is the ideal tool to further elucidate correlations of oxidative stress and disease states.
Uric Acid, the body’s most abundant antioxidant to combat oxidative stress, has emerged as a recognized marker for cardiovascular disease (CVD). Decades of epidemiological and clinical evidence have shown correlation between elevated serum uric acid concentrations and cardiovascular disease risk (1-8), as well as in association with hypertension, diabetes, obesity, preeclampsia, gout, metabolic syndrome and congestive heart failure. Now, this promising biomarker can be accessed via an exciting salivary assay just released from Salimetrics!
While uric acid is a critical antioxidant in blood, in excess, it can have deleterious pro-oxidant activities and increases in oxidative stress. Hyperuricemia, most often associated with gout, has also been strongly correlated with many chronic conditions including cardiovascular disease, kidney disease, metabolic syndrome and diabetes. Hyperuricemia is estimated to affect over 21% of the US population, and doubles in frequency between ages 20 and 80 years old (9). Symptomatic cardiovascular disease in later life is often the result of decades-long progression of atherosclerosis of blood vessels and a current study has detectable elevated Uric Acid as early as adolescence (10).
With the rising incidence of cardiovascular disease in the western world, the medical community seeks novel approaches to identify patients at the greatest risk for cardiovascular disease and other life-threatening conditions in order to suggest lifestyle changes that can prevent or delay these diseases. Salimetrics provides the tools and services, to engage and tackle scientific questions and more clearly define uric acid’s complex biological relationship to common health effects on a broad scale.
- Chen JH, et al. (2009). Serum uric acid level as an independent risk factor for all-cause, cardiovascular, and ischemic stroke mortality: A Chinese cohort study. Arthritis & Rheumatism. 61: 225–232.
- Zoppini G, et al. (2009). Elevated Serum Uric Acid Concentrations Independently Predict Cardiovascular Mortality in Type 2 Diabetic Patients. Diabetes Care. 32(9):1716-20
- Viazzi F, et al. (2014). Serum uric acid and its relationship with metabolic syndrome and cardiovascular risk profile in patients with hypertension: insights from the I-DEMAND study. Nutrition, Metabolism and Cardiovascular Diseases. 24.8: 921-927.
- Gagliardi AC, et al. (2009). Uric acid: A marker of increased cardiovascular risk. Atherosclerosis.
- Fang J, et al. (2000). Serum uric acid and cardiovascular mortality: the NHANES I epidemiologic follow-up study, 1971-1992. Jama. 10;283(18):2404-10.
- Kivity S, et al. (2013). Association of Serum Uric Acid and Cardiovascular Disease in Healthy Adults. American Journal of Cardiology. 15;111(8).
- Lippi G, et al. (2008). The paradoxical relationship between serum uric acid and cardiovascular disease. Clin Chim Acta. 392:1–7.
- Keenan RT, et al. (2009). Hyperuricemia, gout, and cardiovascular disease–an important “muddle”. Bull NYU Hosp Jt Dis. 67(3):285-90.
- Zhu Y, et al (2011). Prevalence of gout and hyperuricemia in the US general population: the National Health and Nutrition Examination Survey 2007-2008. Arthritis Rheum. 63(10):3136-41
- Gonçalves, Jean-Pierre, et al. (2015). “Serum uric acid and cardiovascular risk among Portuguese adolescents.” Journal of Adolescent Health 56.4. 376-381.
- Al-Rawi NH. (2011). Oxidative stress, antioxidant status and lipid profile in the saliva of Type 2 diabetics. Diabetes and Vascular Disease Research. 8(1) 22 –28.
Salimetrics’ assay kits and CLIA-certified testing services are used to measure salivary analytes related to stress, behavior and development, inflammation, sleep, reproduction, health and immune function. Founded in 1998 by Douglas A. Granger, Ph.D., Salimetrics, LLC support CROs, pharmaceuticals, academic researchers and the immunodiagnostic industry around the world with innovative immunoassay products, non-invasive saliva collection methods, and laboratory testing services.
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