It appears that your browser may be outdated and performance may be limited. The My Study builder is best viewed with the latest internet browsers. However, if you’d prefer to use our standard form, you can access it below.

Go to Internet Explorer Quick Quote Form

Dismiss this message

Salivary Bioscience News

Salivary and serum inflammatory markers relate to worse self rated health

Salivary and Serum Analytes and Their Associations with Self-rated Health Among Healthy Young Adults

Majeno, A., Granger, D., Bryce, C.I., & Riis, J. L. 2024, International Journal of Behavioral Medicine

“We examined how various biological markers of inflammation and metabolism measured in saliva and blood related to how healthy young adults rated their health. Higher concentrations of inflammatory markers in saliva and serum were associated with a greater probability of self-rating health as “poor.” Our results have implications for assessing inflammatory markers to help predict risk for poor health and disease.” – Angelina Majeno, Ph.D.

ABSTRACT:

Background: Understanding the biological processes underlying poor self-rated health (SRH) can inform prevention efforts. The COVID-19 pandemic highlighted the importance of using self-reported measures and self-collected biospecimens, such as saliva, to understand physiological functioning and assist with health surveillance and promotion. However, the associations between salivary analytes and SRH remain understudied. The current study addresses this gap.

Methods: In a laboratory-based study, 99 healthy adults (Mage = 23.8 years, SD = 4.5, 55% men, 43% non-Hispanic White) reported their SRH and provided saliva and blood samples that were assayed for adiponectin, C-reactive protein (CRP), uric acid (UA), and cytokines (IL-1β, IL-6, IL-8, TNF-α). Principal component analyses assessed the component loadings and generated factor scores for saliva and serum analytes. Binary logistic regressions examined the associations between these components and poor SRH.

Results: Salivary analytes loaded onto two components (component 1: adiponectin and cytokines; component 2: CRP and UA) explaining 58% of the variance. Serum analytes grouped onto three components (component 1: IL-8 and TNF-α; component 2: CRP, IL-1β, and IL-6; component 3: adiponectin and UA) explaining 76% of the variance. Higher salivary component 1 scores predicted higher odds of reporting poor SRH (OR 1.53, 95%CI [1.10, 2.11]). Higher serum component 2 scores predicted higher odds of reporting poor SRH (OR 2.37, 95%CI [1.20, 4.67]). When examined in the same model, salivary component 1 (OR 1.79, 95%CI [1.17, 2.75]) and serum component 2 were associated with poorer SRH (OR 7.74, 95%CI [2.18, 27.40]).

Conclusions: In our sample, whether measured in saliva or serum, indices of inflammatory processes were associated with SRH.

Keywords: Self-rated health · Subjective health · Saliva · Serum · Inflammation · Cytokine · C-Reactive protein

*Note: Salimetrics provides this information for research use only (RUO). Information is not provided to promote off-label use of medical devices. Please consult the full-text article.

WordPress Cookie Plugin by Real Cookie Banner
Contact: Salimetrics (USA)
View All International Distributors

Test Your DBS samples with Salimetrics!

Experts in Saliva & Dried Blood Spot Testing for Research

The best science for your study

Learn More

OR CALL 800.790.2258

X
Collaboratory