5-HTTLPR variation may influence the impact of early adversity on HPA-axis regulation
Individual Differences in Early Adolescents’ Latent Trait Cortisol: Interaction of Early Adversity and 5-HTTLPR.
Author: Chen FR, et al. (2017), Biol Psychol.
The present study aimed to examine the interaction of 5-HTTLPR and early adversity on trait-like levels of cortisol. A community sample of 117 early adolescent girls (M age=12.39years) provided DNA samples for 5-HTTLPR genotyping, and saliva samples for assessing cortisol 3 times a day (waking, 30min post-waking, and bedtime) over a three-day period. Latent trait cortisol (LTC) was modeled using the first 2 samples of each day. Early adversity was assessed with objective contextual stress interviews with adolescents and their mothers. A significant 5-HTTLPR×early adversity interaction indicated that greater early adversity was associated with lower LTC levels, but only among individuals with either L/L or S/L genotype. Findings suggest that serotonergic genetic variation may influence the impact of early adversity on individual differences in HPA-axis regulation. Future research should explore whether this interaction contributes to the development of psychopathology through HPA axis functioning.
Keywords: 5-HTTLPR, salivary DNA genotyping, adolescence, early adversity, latent trait cortisol, salivary cortisol
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