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1. How to collect Salivary Neopterin
APPROVED SALIVARY NEOPTERIN COLLECTION METHODS
Salivary Neopterin Collection Protocol
Collection volume, general considerations, and basic guidelines to maximize salivary neopterin sample integrity. Use this analyte-specific collection protocol to plan you collection methodology and sampling schemes.
2. How to Assay for Salivary Neopterin
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3. Technical Summary
| Analyte Summary | |
|---|---|
| Analyte: | Neopterin |
| Aliases: | D erythro neopterin |
| Serum-Saliva Correlation: | NA |
| Optimum Collection Volume: | 125 μL* |
| Assay Summary | |
|---|---|
| Methodology: | ELISA |
| Sensitivity: | 0.51 ng/mL |
| Assay Range: | ------------- |
| Assay Type: | Quantitative |
Background
Neopterin (D erythro neopterin) belongs to a group of compounds known as pteridines, which are derived from the guanosine triphosphate (GTP), a purine nucleotide. Neopterin is produced by macrophages, and it is a valuable marker of inflammation and of the activation of the cell-mediated (Th1-type) immune system. Neopterin levels are also used as a measure of oxidative stress. Elevated neopterin levels have been associated with infection, cardiovascular disease, autoimmune disease, malignant tumors, psychiatric disorders, sleep-disordered breathing, autistic children, and cognitive decline in Alzheimer’s disease. (1,2) Neopterin is measurable in healthy human saliva, and increased salivary levels have been found in patients with periodontal disease, HIV-1 virus infections, and Sjögren’s Syndrome. (3,4,5)
References & Salivary Neopterin Research
- Murr, C., Widner, B., Wirleitner, B., Fuchs, D. (2002). Neopterin as a marker for immune system activation. Curr Drug Metab, 3(2), 175-87.
- Chauhan, A., Chauhan, V. (2006). Oxidative stress in autism. Pathophysiology, 13(3), 171-81.
- Katoh, S., Sueoka, T., Matsuura, S., Sugimoto, T. (1989). Biopterin and neopterin in human saliva. Life Sci, 45(26), 2561-68.
- Reibnegger, G., Fuchs, D., Zangerle, R., Wachter, H. (1990). Increased neopterin concentration in saliva of patients with HIV-1 infection. Clin Chem, 36(7), 1379-80.
- Pradeep, A.R., Kumar, M.S., Ramachandraprasad, M.V., Shikha, C. (2007). Gingival crevicular fluid levels of neopterin in healthy subjects and in patients with different periodontal diseases. J Periodontol, 78(10), 1962-67.