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Salivary Neopterin

Salivary Neopterin Quick Start Research Guide

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1. How to collect Salivary Neopterin


Passive Drool Saliva Collection Kit

SalivaBio Passive Drool Method

Use With: Adults, Children 6+

Salivary Neopterin Collection Protocol

Collection volume, general considerations, and basic guidelines to maximize salivary neopterin sample integrity. Use this analyte-specific collection protocol to plan you collection methodology and sampling schemes.


2. How to Assay for Salivary Neopterin

Easy and accurate results from the most trusted Salivary Bioscience Laboratory.

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3. Technical Summary

Analyte Summary
Analyte: ​​Neopterin
Aliases: D erythro neopterin
Serum-Saliva Correlation: NA
Optimum Collection Volume: 125 μL*
*Add 300 µl to the total volume of all tests for liquid handling
Assay Summary
Methodology: ELISA
Sensitivity: 0.51 ng/mL
Assay Range: -------------
Assay Type: Quantitative


​​Neopterin (D erythro neopterin) belongs to a group of compounds known as pteridines, which are derived from the guanosine triphosphate (GTP), a purine nucleotide.  Neopterin is produced by macrophages, and it is a valuable marker of inflammation and of the activation of the cell-mediated (Th1-type) immune system.  Neopterin levels are also used as a measure of oxidative stress.  Elevated neopterin levels have been associated with infection, cardiovascular disease, autoimmune disease, malignant tumors, psychiatric disorders, sleep-disordered breathing, autistic children, and cognitive decline in Alzheimer’s disease.  (1,2)  Neopterin is measurable in healthy human saliva, and increased salivary levels have been found in patients with periodontal disease, HIV-1 virus infections, and Sjögren’s Syndrome. (3,4,5) ​

References & Salivary ​​Neopterin Research

  1. Murr, C., Widner, B., Wirleitner, B., Fuchs, D. (2002).  Neopterin as a marker for immune system activation.  Curr Drug Metab, 3(2), 175-87.
  2. Chauhan, A., Chauhan, V. (2006).  Oxidative stress in autism.  Pathophysiology, 13(3), 171-81.
  3. Katoh, S., Sueoka, T., Matsuura, S., Sugimoto, T. (1989). Biopterin and neopterin in human saliva.  Life Sci, 45(26), 2561-68.
  4. Reibnegger, G., Fuchs, D., Zangerle, R., Wachter, H. (1990). Increased neopterin concentration in saliva of patients with HIV-1 infection.  Clin Chem, 36(7), 1379-80.
  5. Pradeep, A.R., Kumar, M.S., Ramachandraprasad, M.V., Shikha, C. (2007).  Gingival crevicular fluid levels of neopterin in healthy subjects and in patients with different periodontal diseases.  J Periodontol, 78(10), 1962-67.

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